Enantioselective Michael reaction of ketone lithium enolates using a chiral ligand

Kosuke Yasuda, Mitsuru Shindo, Kenji Koga

Research output: Contribution to journalArticlepeer-review

49 Citations (Scopus)

Abstract

The enantioselective Michael reaction of ketone lithium enolates using a chiral amine ligand (1) was studied. Michael adducts (4) of up to 94% ee were obtained by the reaction between methyl ketones (2) and Michael acceptors (3) having a benzylidene group.

Original languageEnglish
Pages (from-to)6343-6346
Number of pages4
JournalTetrahedron Letters
Volume37
Issue number35
DOIs
Publication statusPublished - Aug 26 1996
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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