Enantioselective polymer prepared by surface imprinting technique using a bifunctional molecule

Kosuke Araki, Masahiro Goto, Shintaro Furusaki

    Research output: Contribution to journalArticlepeer-review

    41 Citations (Scopus)

    Abstract

    An enatioselective surface-imprinted polymer for an amino acid derivative (N-benzyloxycarbonyl-glutamic acid, Z-Glu) was prepared using the bifunctional molecule, benzyldimethyl-n-tetradecylammonium chloride (Zeph). The long-chain quaternary ammonium chloride was found to serve the dual function of an emulsifier and host molecule, while conventional functional molecules possess only the latter function. Chiral recognition ability and ligand specificity of the imprinted polymer were demonstrated by several batchwise tests using different four amino acid derivatives. The surface-imprinted polymer could recognize the chirality of N-protected glutamic acid; therefore, it preferentially adsorbed the corresponding enantiomer that was imprinted in the preparation. The pH and buffer concentration in the aqueous solution are the key factors enhancing enantioselectivity. The molecularly imprinted polymer could distinguish the specific structure from other molecular analogues, even though the structural difference was the only methylene group. The high interfacial activity of the functional molecule and the low swelling property of the imprinted polymer were important in ensuring high imprinting effect. The mechanism of chiral recognition on the polymer was also discussed.

    Original languageEnglish
    Pages (from-to)173-181
    Number of pages9
    JournalAnalytica Chimica Acta
    Volume469
    Issue number2
    DOIs
    Publication statusPublished - Oct 3 2002

    All Science Journal Classification (ASJC) codes

    • Analytical Chemistry
    • Biochemistry
    • Environmental Chemistry
    • Spectroscopy

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