Enantioselective Synthesis of Silacyclopentanes

Kazunobu Igawa, Daisuke Yoshihiro, Yusuke Abe, Katsuhiko Tomooka

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

A variety of functionalized silacyclopentanes were synthesized by highly enantioselective β-eliminations of silacyclopentene oxides followed by stereospecific transformations. The reaction mechanism of the β-elimination was elucidated by DFT calculations. An in vitro biological assay with an oxy-functionalized silacyclopentane showed substantial binding to a serotonin receptor protein.

Original languageEnglish
Pages (from-to)5814-5818
Number of pages5
JournalAngewandte Chemie - International Edition
Volume55
Issue number19
DOIs
Publication statusPublished - May 4 2016

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Serotonin Receptors
Discrete Fourier transforms
Oxides
Assays
Proteins

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

Cite this

Enantioselective Synthesis of Silacyclopentanes. / Igawa, Kazunobu; Yoshihiro, Daisuke; Abe, Yusuke; Tomooka, Katsuhiko.

In: Angewandte Chemie - International Edition, Vol. 55, No. 19, 04.05.2016, p. 5814-5818.

Research output: Contribution to journalArticle

Igawa, Kazunobu ; Yoshihiro, Daisuke ; Abe, Yusuke ; Tomooka, Katsuhiko. / Enantioselective Synthesis of Silacyclopentanes. In: Angewandte Chemie - International Edition. 2016 ; Vol. 55, No. 19. pp. 5814-5818.
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