Enantioselective Synthesis of Silacyclopentanes

Kazunobu Igawa, Daisuke Yoshihiro, Yusuke Abe, Katsuhiko Tomooka

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

A variety of functionalized silacyclopentanes were synthesized by highly enantioselective β-eliminations of silacyclopentene oxides followed by stereospecific transformations. The reaction mechanism of the β-elimination was elucidated by DFT calculations. An in vitro biological assay with an oxy-functionalized silacyclopentane showed substantial binding to a serotonin receptor protein.

Original languageEnglish
Pages (from-to)5814-5818
Number of pages5
JournalAngewandte Chemie - International Edition
Volume55
Issue number19
DOIs
Publication statusPublished - May 4 2016

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

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