Encapsulation of myoglobin in PEGylated polyion complex vesicles made from a pair of oppositely charged block ionomers

A physiologically available oxygen carrier

Akihiro Kishimura, Aya Koide, Kensuke Osada, Yuichi Yamasaki, Kazunori Kataoka

Research output: Contribution to journalArticle

153 Citations (Scopus)

Abstract

(Figure Presented) Take your PIC: Biologically active polyion complex vesicles (PICsomes) with encapsulated myoglobin (Mb) can be prepared by the self-assembly of a pair of oppositely charged block ionomers with polyethylene glycol (PEG) segments (see picture; metMb: metmyoglobin). The loaded Mb maintains reversible oxygenation even in the presence of trypsin.

Original languageEnglish
Pages (from-to)6085-6088
Number of pages4
JournalAngewandte Chemie - International Edition
Volume46
Issue number32
DOIs
Publication statusPublished - Aug 27 2007
Externally publishedYes

Fingerprint

Oxygenation
Ionomers
Myoglobin
Encapsulation
Self assembly
Polyethylene glycols
Metmyoglobin
Oxygen
Trypsin

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Cite this

Encapsulation of myoglobin in PEGylated polyion complex vesicles made from a pair of oppositely charged block ionomers : A physiologically available oxygen carrier. / Kishimura, Akihiro; Koide, Aya; Osada, Kensuke; Yamasaki, Yuichi; Kataoka, Kazunori.

In: Angewandte Chemie - International Edition, Vol. 46, No. 32, 27.08.2007, p. 6085-6088.

Research output: Contribution to journalArticle

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