TY - JOUR
T1 - Endocytic recycling at the tip region in the filamentous fungus Aspergillus oryzae
AU - Higuchi, Yujiro
AU - Arioka, Manabu
AU - Kitamoto, Katsuhiko
N1 - Funding Information:
Y.H. was supported by research fellowships for young scientists from the Japan Society for the Promotion of Science. This study was supported by Grant-in-Aid for Scientific Research (S) and Grant-in-Aid for Scientific Research on Priority Areas “Applied Genomics” from the Ministry of Education, Culture, Sports, Science and Technology of Japan.
PY - 2009/7
Y1 - 2009/7
N2 - Recent live cell imaging analyzing the components required for endocytosis has elucidated that endocytosis actively occurs at the hyphal tip region in filamentous fungi. To examine further the physiological roles of endocytosis we investigated a conditional mutant of endocytosis in Aspergillus oryzae. Endocytosis-deficient hyphae displayed retarded apical growth, abnormal hyphal morphology, mislocalization of a vesicle-SNARE, which is thought to undergo endocytic recycling to the tip region, and aberrant accumulation of cell wall components at large invaginated structures. These results suggest that endocytosis is crucial for apical growth and for recycling components, which should be re-transported to the tip region. In this report, we discuss the endocytic recycling pathway and present its possible mechanism in filamentous fungi.
AB - Recent live cell imaging analyzing the components required for endocytosis has elucidated that endocytosis actively occurs at the hyphal tip region in filamentous fungi. To examine further the physiological roles of endocytosis we investigated a conditional mutant of endocytosis in Aspergillus oryzae. Endocytosis-deficient hyphae displayed retarded apical growth, abnormal hyphal morphology, mislocalization of a vesicle-SNARE, which is thought to undergo endocytic recycling to the tip region, and aberrant accumulation of cell wall components at large invaginated structures. These results suggest that endocytosis is crucial for apical growth and for recycling components, which should be re-transported to the tip region. In this report, we discuss the endocytic recycling pathway and present its possible mechanism in filamentous fungi.
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U2 - 10.4161/cib.2.4.8385
DO - 10.4161/cib.2.4.8385
M3 - Article
C2 - 19721880
AN - SCOPUS:69249097082
SN - 1942-0889
VL - 2
SP - 327
EP - 328
JO - Communicative and Integrative Biology
JF - Communicative and Integrative Biology
IS - 4
ER -