Endogenous angiotensin II in the NTS contributes to sympathetic activation in rats with aortocaval shunt

Hideaki Shigematsu, Yoshitaka Hirooka, Kenichi Eshima, Miwako Shihara, Tatsuya Tagawa, Akira Takeshita

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Recent studies have suggested that the central nervous system is responsible for activation of sympathetic nerve activity (SNA) and the renin-angiotensin system in heart failure (HF). The aim of this study was to determine whether activation of the renin-angiotensin system within the nucleus of the solitary tract (NTS) plays a role in enhanced SNA in HF. High-output HF was induced by an aortocaval (A-V) shunt with some modifications in the rat. These rats exhibited a left ventricular dilatation and hemodynamic signs of high-output HF. Urinary catecholamine excretion and maximal renal SNA (RSNA) were greater in the A-V shunted rats than in the control rats. Microinjection of an angiotensin II type 1-receptor antagonist, CV11974, into the NTS was performed. The arterial pressure and RSNA were reduced by CV11974 to a greater degree in the A-V shunted rats than in the control rats. The expression of angiotensin-converting enzyme mRNA in the medulla was greater in the A-V shunted rats than in the control rats. These results suggest that activation of the renin-angiotensin system within the NTS contributes to an enhanced SNA in this model.

Original languageEnglish
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume280
Issue number6 49-6
Publication statusPublished - Jul 3 2001

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Angiotensin II
Renin-Angiotensin System
Heart Failure
Angiotensin II Type 1 Receptor Blockers
Solitary Nucleus
Microinjections
Peptidyl-Dipeptidase A
Catecholamines
Dilatation
Arterial Pressure
Central Nervous System
Hemodynamics
Kidney
Messenger RNA

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

Endogenous angiotensin II in the NTS contributes to sympathetic activation in rats with aortocaval shunt. / Shigematsu, Hideaki; Hirooka, Yoshitaka; Eshima, Kenichi; Shihara, Miwako; Tagawa, Tatsuya; Takeshita, Akira.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 280, No. 6 49-6, 03.07.2001.

Research output: Contribution to journalArticle

Shigematsu, Hideaki ; Hirooka, Yoshitaka ; Eshima, Kenichi ; Shihara, Miwako ; Tagawa, Tatsuya ; Takeshita, Akira. / Endogenous angiotensin II in the NTS contributes to sympathetic activation in rats with aortocaval shunt. In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 2001 ; Vol. 280, No. 6 49-6.
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