Endogenous cholecystokinin is not a major regulator of food intake in the chicken

Y. H. Choi, Mitsuhiro Furuse, S. Satoh, J. Okumura

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

This study investigated whether or not endogenous cholecystokinin exerts satiety effects in chickens. After several doses (0, 1, 2 and 4 μg·kg body weight-1) of intravenous injection of caerulein, the bile flow was increased in a dose-dependent fashion. However, the pharmacological level of caerulein failed to suppress the food intake of chickens. Two potent stimulators of endogenous cholecystokinin, i.e., soybean trypsin inhibitor and phenylalanine were administered to chickens before feeding and food intake was determined over 2 h. The soybean trypsin inhibitor and phenylalanine did not alter food intake. Devazepide, a cholecystokinin-A receptor antagonist, significantly decreased amylase release from the dispersed chicken pancreatic acini stimulated by caerulein. However, devazepide did not improve food intake of the chicken. The results obtained suggest that endogenous cholecystokinin may not act as a satiety signal in chickens.

Original languageEnglish
Pages (from-to)425-429
Number of pages5
JournalJournal of Comparative Physiology B
Volume164
Issue number6
DOIs
Publication statusPublished - Jan 1 1994

Fingerprint

cholecystokinin
Cholecystokinin
food intake
Ceruletide
Chickens
Eating
Devazepide
chickens
Trypsin Inhibitors
Phenylalanine
soybean
inhibitor
Cholecystokinin A Receptor
trypsin inhibitors
satiety
Soybeans
phenylalanine
Amylases
soybeans
bile

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Biochemistry
  • Physiology
  • Animal Science and Zoology
  • Endocrinology

Cite this

Endogenous cholecystokinin is not a major regulator of food intake in the chicken. / Choi, Y. H.; Furuse, Mitsuhiro; Satoh, S.; Okumura, J.

In: Journal of Comparative Physiology B, Vol. 164, No. 6, 01.01.1994, p. 425-429.

Research output: Contribution to journalArticle

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