Endogenous IL-15 might be responsible for early protection by natural killer cells against infection with an avirulent strain of Salmonella choleraesuis in mice

Kenji Hirose, Hitoshi Nishimura, Tetsuya Matsuguchi, Yasunobu Yoshikai

    Research output: Contribution to journalArticlepeer-review

    36 Citations (Scopus)

    Abstract

    Interleukin (IL)-15 is a novel cytokine with growth factor activity for T cells, B cells, and natural killer cells (NK cells). We investigated the role of IL-15 in the host defense against infection with avirulent Salmonella choleraesuis strain 31N-1 cured of 50-kb virulent plasmid. IL-15 was abundantly expressed at transcription and protein levels in macrophages infected with S. choleraesuis 31N-1. The number of NK cells in the infected sites was increased during the course of infection coincident with IL-15 production. Anti-IL-15 mAb administration inhibited the emergence of NK cells and interferon-γ (IFN-γ) production in serum after infection with S. choleraesuis 31N-1 and concurrently impaired the clearance of the bacteria. These results suggested that IL-15 might be responsible for protection against avirulent S. choleraesuis infection at early stage of infection through activation of NK cells in the infected sites.

    Original languageEnglish
    Pages (from-to)382-390
    Number of pages9
    JournalJournal of Leukocyte Biology
    Volume66
    Issue number3
    DOIs
    Publication statusPublished - 1999

    All Science Journal Classification (ASJC) codes

    • Immunology and Allergy
    • Immunology
    • Cell Biology

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