TY - JOUR
T1 - Endometrial carcinoma associated with hyperplasia
AU - Kaku, Tsunehisa
AU - Tsukamoto, Naoki
AU - Hachisuga, Tooru
AU - Tsuruchi, Nobuhiro
AU - Sakai, Kunihiro
AU - Hirakawa, Toshio
AU - Amada, Satoshi
AU - Saito, Toshiaki
AU - Kamura, Toshiharu
AU - Nakano, Hitoo
N1 - Funding Information:
This work was supported by a Grant-in-Aid for Scientific Research (c) (Nos. 07671799, 07671800, 06671662, and 05454452) from the Ministry of Education, Science and Culture, Japan. We thank Dr. Steven G. Sil-verberg for reviewing and assisting with the manuscript.
PY - 1996/1
Y1 - 1996/1
N2 - The aim of this study was to clarify the relationship of endometrial hyperplasia to endometrial carcinoma. From 1979 through 1990, 115 cases of stage I-IV endometrial carcinomas treated initially by hysterectomy were reviewed histologically. Forty-two of 115 (36.5%) patients had hyperplasia in the endometrium adjacent to the carcinoma. Women with both endometrial carcinoma and hyperplasia were significantly younger than those with carcinoma without hyperplasia (P < 0.05). In a comparison of patients with carcinoma without hyperplasia, those with hyperplasia were better differentiated (P = 0.0072), and lacked deep myometrial invasion (P < 0.0001), cervical involvement (P = 0.0192), lymph-vascular space invasion (P = 0.0102), and para-aortic lymph node metastase (P = 0.0434). The presence of hyperplasia was also significantly correlated with the presence of endometrial metaplasia (P = 0.0001). The estimated 5-year survival rates for patients with carcinoma with hyperplasia and those with carcinoma without hyperplasia were 96.55 and 73.33%, respectively (P = 0.0016). In endometrial carcinomas, the presence of endometrial hyperplasia may demonstrate a more favorable prognosis.
AB - The aim of this study was to clarify the relationship of endometrial hyperplasia to endometrial carcinoma. From 1979 through 1990, 115 cases of stage I-IV endometrial carcinomas treated initially by hysterectomy were reviewed histologically. Forty-two of 115 (36.5%) patients had hyperplasia in the endometrium adjacent to the carcinoma. Women with both endometrial carcinoma and hyperplasia were significantly younger than those with carcinoma without hyperplasia (P < 0.05). In a comparison of patients with carcinoma without hyperplasia, those with hyperplasia were better differentiated (P = 0.0072), and lacked deep myometrial invasion (P < 0.0001), cervical involvement (P = 0.0192), lymph-vascular space invasion (P = 0.0102), and para-aortic lymph node metastase (P = 0.0434). The presence of hyperplasia was also significantly correlated with the presence of endometrial metaplasia (P = 0.0001). The estimated 5-year survival rates for patients with carcinoma with hyperplasia and those with carcinoma without hyperplasia were 96.55 and 73.33%, respectively (P = 0.0016). In endometrial carcinomas, the presence of endometrial hyperplasia may demonstrate a more favorable prognosis.
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U2 - 10.1006/gyno.1996.0005
DO - 10.1006/gyno.1996.0005
M3 - Article
C2 - 8557221
AN - SCOPUS:0030058384
SN - 0090-8258
VL - 60
SP - 22
EP - 25
JO - Gynecologic Oncology
JF - Gynecologic Oncology
IS - 1
ER -