Endometrial metaplasia associated with endometrial carcinoma

Tsunehisa Kaku, Naoki Tsukamoto, Nobuhiro Tsuruchi, Kouichiro Sugihara, Toshiharu Kamura, Hitoo Nakano

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

To clarify the relationship of metaplasia to endometrial carcinoma.Methods: Between 1984-1990, 73 cases of stage I-II endometrial carcinoma treated initially by hysterectomy were reviewed histologically. The metaplasias were classified as squamous, syncytial papillary, ciliated-cell, eosinophilic, mucinous, dear-cell, or hobnail. We assessed the histologic type and grade of the carcinoma, depth of myometrial invasion, presence or absence of lymph-vascular space invasion, and presence or absence of lymph node metastases.Results: Forty of 73 patients (55%) had one or more areas of metaplasia in the endometrium adjacent to the carcinoma. Ciliated-cell metaplasia (28 of 73; 38%) was the most common type encountered. Women with both endometrial carcinoma and metaplasia were significantly younger than those with carcinoma without metaplasia (P < .05). Compared with carcinomas without metaplasia, those with metaplasia were well differentiated (P < .01) and lacked myometrial invasion (P < .01) and pelvic lymph node metastases (P < .05). The presence of metaplasia was also significantly correlated with the presence of endometrial hyperplasia (P < .01).Conclusion: In endometrial carcinomas, the presence of endometrial metaplasia suggests a favorable prognosis.

Original languageEnglish
Pages (from-to)812-816
Number of pages5
JournalObstetrics and Gynecology
Volume80
Issue number5
Publication statusPublished - Jan 1 1992

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Metaplasia
Endometrial Neoplasms
Carcinoma
Lymph Nodes
Neoplasm Metastasis
Endometrial Hyperplasia
Lymph
Endometrium
Hysterectomy
Blood Vessels

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology

Cite this

Kaku, T., Tsukamoto, N., Tsuruchi, N., Sugihara, K., Kamura, T., & Nakano, H. (1992). Endometrial metaplasia associated with endometrial carcinoma. Obstetrics and Gynecology, 80(5), 812-816.

Endometrial metaplasia associated with endometrial carcinoma. / Kaku, Tsunehisa; Tsukamoto, Naoki; Tsuruchi, Nobuhiro; Sugihara, Kouichiro; Kamura, Toshiharu; Nakano, Hitoo.

In: Obstetrics and Gynecology, Vol. 80, No. 5, 01.01.1992, p. 812-816.

Research output: Contribution to journalArticle

Kaku, T, Tsukamoto, N, Tsuruchi, N, Sugihara, K, Kamura, T & Nakano, H 1992, 'Endometrial metaplasia associated with endometrial carcinoma', Obstetrics and Gynecology, vol. 80, no. 5, pp. 812-816.
Kaku T, Tsukamoto N, Tsuruchi N, Sugihara K, Kamura T, Nakano H. Endometrial metaplasia associated with endometrial carcinoma. Obstetrics and Gynecology. 1992 Jan 1;80(5):812-816.
Kaku, Tsunehisa ; Tsukamoto, Naoki ; Tsuruchi, Nobuhiro ; Sugihara, Kouichiro ; Kamura, Toshiharu ; Nakano, Hitoo. / Endometrial metaplasia associated with endometrial carcinoma. In: Obstetrics and Gynecology. 1992 ; Vol. 80, No. 5. pp. 812-816.
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