Endoscopic features of chronic nonspecific multiple ulcers of the small intestine: Comparison with nonsteroidal anti-inflammatory drug-induced enteropathy

Takayuki Matsumoto, Shotaro Nakamura, Motohiro Esaki, Shinnichiro Yada, Hideki Koga, Takashi Yao, Mitsuo Iida

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Chronic nonspecific multiple ulcers of the small intestine (CNSU) and nonsteroidal anti-inflammatory drug-induced enteropathy (NSAID-enteropathy) share common clinicopathologic features characterized by histologically nonspecific ulcers and persistent blood loss. The aim was to compare enteroscopic findings between CNSU and NSAID-enteropathy. Four patients with CNSU and five patients with NSAID-enteropathy were examined by enteroscopies. The site of involvement was heterogeneous in NSAID-enteropathy, while the ileum was the predominant site in CNSU. Three patients with NSAID-enteropathy and all four patients with CNSU had concentric stenosis. Circular ulcers were found in all five patients with NSAID-enteropathy and in three patients with CNSU. Active ulcer was seen in only two patients with NSAID-enteropathy. In contrast, all four patients with CNSU had active ulcer. These findings suggest that in patients with persistent GI bleeding and enteroscopically active small intestinal ulcers, CNSU, as well as NSAID-enteropathy, should be considered.

Original languageEnglish
Pages (from-to)1357-1363
Number of pages7
JournalDigestive Diseases and Sciences
Volume51
Issue number8
DOIs
Publication statusPublished - Aug 2006

All Science Journal Classification (ASJC) codes

  • Physiology
  • Gastroenterology

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