Endoscopic injection sclerotherapy for 1,000 patients with esophageal varices

A nine‐year prospective study

Makoto Hashizume, Seigo Kitano, Nobuhiro Koyanagi, Kazuo Tanoue, Masayuki Ohta, Hiroya Wada, Hirohiko Yamaga, Hidefumi Higashi, Yasunori Iso, Tetsuya Iwanaga, Keizo Sugimachi

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

We report here the results of endoscopic injection sclerotherapy performed in 1,000 consecutively treated Japanese patients with esophageal varices. This prospective study covered the period from 1982 to 1990. Variceal bleeding was controlled in 215 (97.7%) of 220 patients. Esophageal varices were completely eradicated in 778 patients (77.8%); the mean number of sessions was 4.2. In only 3 of the 778 patients did esophageal varices of the same size recur. Small, dilated, venous vessels that required additional sclerotherapy in follow‐up endoscopy at 3‐mo intervals appeared in 171 (22.2%) of 778 patients. The cumulative nonbleeding rate at 5 yr was 94.5% in patients in whom the varices had been eradicated. Deaths caused by upper gastrointestinal bleeding accounted for 2.6% of cases, whereas the rates of liver failure and hepatoma were 4.6% and 47.3%, respectively. The 5‐yr cumulative survival rate was 54.1% in patients without concomitant hepatoma; it was 12.0% in patients with hepatomas. Multivariate analysis showed that hepatoma, Child classification, indication (acute, elective or prophylactic) and eradication were independent factors that significantly influenced survival time. This study clearly shows that close follow‐up with endoscopy and complete eradication lead to significant reduction in bleeding from esophageal varices and reduction of mortality related to this bleeding. (HEPATOLOGY 1992;15:69–75).

Original languageEnglish
Pages (from-to)69-75
Number of pages7
JournalHepatology
Volume15
Issue number1
DOIs
Publication statusPublished - Jan 1 1992

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Sclerotherapy
Esophageal and Gastric Varices
Prospective Studies
Injections
Hepatocellular Carcinoma
Hemorrhage
Endoscopy
Liver Failure
Varicose Veins
Multivariate Analysis
Survival Rate
Survival
Mortality

All Science Journal Classification (ASJC) codes

  • Hepatology

Cite this

Hashizume, M., Kitano, S., Koyanagi, N., Tanoue, K., Ohta, M., Wada, H., ... Sugimachi, K. (1992). Endoscopic injection sclerotherapy for 1,000 patients with esophageal varices: A nine‐year prospective study. Hepatology, 15(1), 69-75. https://doi.org/10.1002/hep.1840150114

Endoscopic injection sclerotherapy for 1,000 patients with esophageal varices : A nine‐year prospective study. / Hashizume, Makoto; Kitano, Seigo; Koyanagi, Nobuhiro; Tanoue, Kazuo; Ohta, Masayuki; Wada, Hiroya; Yamaga, Hirohiko; Higashi, Hidefumi; Iso, Yasunori; Iwanaga, Tetsuya; Sugimachi, Keizo.

In: Hepatology, Vol. 15, No. 1, 01.01.1992, p. 69-75.

Research output: Contribution to journalArticle

Hashizume, M, Kitano, S, Koyanagi, N, Tanoue, K, Ohta, M, Wada, H, Yamaga, H, Higashi, H, Iso, Y, Iwanaga, T & Sugimachi, K 1992, 'Endoscopic injection sclerotherapy for 1,000 patients with esophageal varices: A nine‐year prospective study', Hepatology, vol. 15, no. 1, pp. 69-75. https://doi.org/10.1002/hep.1840150114
Hashizume, Makoto ; Kitano, Seigo ; Koyanagi, Nobuhiro ; Tanoue, Kazuo ; Ohta, Masayuki ; Wada, Hiroya ; Yamaga, Hirohiko ; Higashi, Hidefumi ; Iso, Yasunori ; Iwanaga, Tetsuya ; Sugimachi, Keizo. / Endoscopic injection sclerotherapy for 1,000 patients with esophageal varices : A nine‐year prospective study. In: Hepatology. 1992 ; Vol. 15, No. 1. pp. 69-75.
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