Abstract
A group of 1127 patients who underwent sclerotherapy for esophageal varices were compared for outcome in terms of age: over and ander age 70 years. Esophageal varices were completely eradicated in 81 of 110 patients >70 years (73.6%) and in 791 of 1017 patients <70 years (77.8%). Gastrointestinal bleeding after sclerotherapy occurred in 9 patients >70 years (8.2%) and in 84 of those <70 years (8.3%). Complications occurred in 16 patients >70 years (14.5%) and in 141 <70 years (13.9%). Liver failure and hepatoma accounted for more than 80% of the causes of death in both groups (80.3% versus 83.8%). The 5-year cumulative survival rates in patients with bleeding esophageal varices (bleeders) without hepatoma were 21.8% in those >70 years and 58.7% in those <70 years (p<0.01), the relative survivals being 25.3% versus 66.6%. Patients without hepatoma and treated by prophylactic sclerotherapy accounted for 66.2% of patients >70 years and 61.7% of those <70 years, the relative survivals being 75.9% versus 71.9%. As analyzed by the Cox proportional-hazards model, age >70 years was a prognostic factor in the bleeders (p<0.01) but not in the nonbleeders. We recommend that elderly patients with esophageal varices be given prophylactic sclerotherapy, as the outcome for these patients is poor once bleeding has occurred.
| Original language | English |
|---|---|
| Pages (from-to) | 764-768 |
| Number of pages | 5 |
| Journal | World journal of surgery |
| Volume | 18 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Sep 1 1994 |
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All Science Journal Classification (ASJC) codes
- Surgery
Cite this
Endoscopic injection sclerotherapy for esophageal varices in the elderly. / Ohta, Masayuki; Hashizume, Makoto; Kamakura, Tatsuro; Ueno, Kiichiro; Tomikawa, Morimasa; Tanoue, Kazuo; Kitano, Seigo; Sugimachi, Keizo.
In: World journal of surgery, Vol. 18, No. 5, 01.09.1994, p. 764-768.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Endoscopic injection sclerotherapy for esophageal varices in the elderly
AU - Ohta, Masayuki
AU - Hashizume, Makoto
AU - Kamakura, Tatsuro
AU - Ueno, Kiichiro
AU - Tomikawa, Morimasa
AU - Tanoue, Kazuo
AU - Kitano, Seigo
AU - Sugimachi, Keizo
PY - 1994/9/1
Y1 - 1994/9/1
N2 - A group of 1127 patients who underwent sclerotherapy for esophageal varices were compared for outcome in terms of age: over and ander age 70 years. Esophageal varices were completely eradicated in 81 of 110 patients >70 years (73.6%) and in 791 of 1017 patients <70 years (77.8%). Gastrointestinal bleeding after sclerotherapy occurred in 9 patients >70 years (8.2%) and in 84 of those <70 years (8.3%). Complications occurred in 16 patients >70 years (14.5%) and in 141 <70 years (13.9%). Liver failure and hepatoma accounted for more than 80% of the causes of death in both groups (80.3% versus 83.8%). The 5-year cumulative survival rates in patients with bleeding esophageal varices (bleeders) without hepatoma were 21.8% in those >70 years and 58.7% in those <70 years (p<0.01), the relative survivals being 25.3% versus 66.6%. Patients without hepatoma and treated by prophylactic sclerotherapy accounted for 66.2% of patients >70 years and 61.7% of those <70 years, the relative survivals being 75.9% versus 71.9%. As analyzed by the Cox proportional-hazards model, age >70 years was a prognostic factor in the bleeders (p<0.01) but not in the nonbleeders. We recommend that elderly patients with esophageal varices be given prophylactic sclerotherapy, as the outcome for these patients is poor once bleeding has occurred.
AB - A group of 1127 patients who underwent sclerotherapy for esophageal varices were compared for outcome in terms of age: over and ander age 70 years. Esophageal varices were completely eradicated in 81 of 110 patients >70 years (73.6%) and in 791 of 1017 patients <70 years (77.8%). Gastrointestinal bleeding after sclerotherapy occurred in 9 patients >70 years (8.2%) and in 84 of those <70 years (8.3%). Complications occurred in 16 patients >70 years (14.5%) and in 141 <70 years (13.9%). Liver failure and hepatoma accounted for more than 80% of the causes of death in both groups (80.3% versus 83.8%). The 5-year cumulative survival rates in patients with bleeding esophageal varices (bleeders) without hepatoma were 21.8% in those >70 years and 58.7% in those <70 years (p<0.01), the relative survivals being 25.3% versus 66.6%. Patients without hepatoma and treated by prophylactic sclerotherapy accounted for 66.2% of patients >70 years and 61.7% of those <70 years, the relative survivals being 75.9% versus 71.9%. As analyzed by the Cox proportional-hazards model, age >70 years was a prognostic factor in the bleeders (p<0.01) but not in the nonbleeders. We recommend that elderly patients with esophageal varices be given prophylactic sclerotherapy, as the outcome for these patients is poor once bleeding has occurred.
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UR - http://www.scopus.com/inward/citedby.url?scp=0028133372&partnerID=8YFLogxK
U2 - 10.1007/BF00298925
DO - 10.1007/BF00298925
M3 - Article
C2 - 7975697
AN - SCOPUS:0028133372
VL - 18
SP - 764
EP - 768
JO - World Journal of Surgery
JF - World Journal of Surgery
SN - 0364-2313
IS - 5
ER -