Abstract
Background. The objective of this study is to examine the overall clinical results of endoscopic injection sclerotherapy (EIS) for patients with esophageal varices in our institution. Methods. From January 1982 to May 2001, 2105 patients with esophageal varices were treated with EIS, which included prophylactic injections for patients with risky varices according to our criteria. Follow-up endoscopy was performed every 3 months, and recurrent varices were treated with additional EIS. Results. Acute variceal bleeding was controlled in 468 of 473 patients (98.9%). Esophageal varices were completely eradicated in 1757 of 2105 patients (83.5%) with 3.8 ± 1.6 sessions of EIS. The cumulative recurrence rates were 32.2% at 5 years, 36.5% at 10 years, and 37.8% at 15 years. The cumulative nonbleeding rates were 92.3% at 5 years, 90.1% at 10 years, and 89.5% at 15 years. The survival rate of acute bleeders was significantly lower than for both elective and prophylactic cases (P < . 05). The overall cumulative survival rate was 28.2% at 10 years. Conclusions. EIS is the first choice of treatment for esophageal variceal bleeding, and rebleeding was shown to be well controlled in a long-term follow-up with endoscopy and additional EIS. The lower survival rate observed in acute bleeders may therefore justify the use of prophylactic EIS.
| Original language | English |
|---|---|
| Pages (from-to) | S171-S175 |
| Journal | Surgery |
| Volume | 131 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 1 2002 |
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All Science Journal Classification (ASJC) codes
- Surgery
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Endoscopic injection sclerotherapy in the management of 2105 patients with esophageal varices. / Tomikawa, Morimasa; Hashizume, Makoto; Okita, Keishi; Kitano, Seigo; Ohta, Masayuki; Higashi, Hidefumi; Akahoshi, Tomohiko.
In: Surgery, Vol. 131, No. 1, 01.01.2002, p. S171-S175.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Endoscopic injection sclerotherapy in the management of 2105 patients with esophageal varices
AU - Tomikawa, Morimasa
AU - Hashizume, Makoto
AU - Okita, Keishi
AU - Kitano, Seigo
AU - Ohta, Masayuki
AU - Higashi, Hidefumi
AU - Akahoshi, Tomohiko
PY - 2002/1/1
Y1 - 2002/1/1
N2 - Background. The objective of this study is to examine the overall clinical results of endoscopic injection sclerotherapy (EIS) for patients with esophageal varices in our institution. Methods. From January 1982 to May 2001, 2105 patients with esophageal varices were treated with EIS, which included prophylactic injections for patients with risky varices according to our criteria. Follow-up endoscopy was performed every 3 months, and recurrent varices were treated with additional EIS. Results. Acute variceal bleeding was controlled in 468 of 473 patients (98.9%). Esophageal varices were completely eradicated in 1757 of 2105 patients (83.5%) with 3.8 ± 1.6 sessions of EIS. The cumulative recurrence rates were 32.2% at 5 years, 36.5% at 10 years, and 37.8% at 15 years. The cumulative nonbleeding rates were 92.3% at 5 years, 90.1% at 10 years, and 89.5% at 15 years. The survival rate of acute bleeders was significantly lower than for both elective and prophylactic cases (P < . 05). The overall cumulative survival rate was 28.2% at 10 years. Conclusions. EIS is the first choice of treatment for esophageal variceal bleeding, and rebleeding was shown to be well controlled in a long-term follow-up with endoscopy and additional EIS. The lower survival rate observed in acute bleeders may therefore justify the use of prophylactic EIS.
AB - Background. The objective of this study is to examine the overall clinical results of endoscopic injection sclerotherapy (EIS) for patients with esophageal varices in our institution. Methods. From January 1982 to May 2001, 2105 patients with esophageal varices were treated with EIS, which included prophylactic injections for patients with risky varices according to our criteria. Follow-up endoscopy was performed every 3 months, and recurrent varices were treated with additional EIS. Results. Acute variceal bleeding was controlled in 468 of 473 patients (98.9%). Esophageal varices were completely eradicated in 1757 of 2105 patients (83.5%) with 3.8 ± 1.6 sessions of EIS. The cumulative recurrence rates were 32.2% at 5 years, 36.5% at 10 years, and 37.8% at 15 years. The cumulative nonbleeding rates were 92.3% at 5 years, 90.1% at 10 years, and 89.5% at 15 years. The survival rate of acute bleeders was significantly lower than for both elective and prophylactic cases (P < . 05). The overall cumulative survival rate was 28.2% at 10 years. Conclusions. EIS is the first choice of treatment for esophageal variceal bleeding, and rebleeding was shown to be well controlled in a long-term follow-up with endoscopy and additional EIS. The lower survival rate observed in acute bleeders may therefore justify the use of prophylactic EIS.
UR - http://www.scopus.com/inward/record.url?scp=0036165404&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036165404&partnerID=8YFLogxK
U2 - 10.1067/msy.2002.119500
DO - 10.1067/msy.2002.119500
M3 - Article
C2 - 11821806
AN - SCOPUS:0036165404
VL - 131
SP - S171-S175
JO - Surgery
JF - Surgery
SN - 0039-6060
IS - 1
ER -