Endothelial Dysfunction in Microvascular Angina

James D. Rossen, Yoram Agmon, Richard Gorlin, E. C. Abbott, Kensuke Egashira, Akira Takeshita

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To the Editor: Egashira et al. (June 10 issue)1 described blunted coronary vasodilation in response to acetylcholine infusion in a group of patients with angina pectoris, positive exercise tests, angiographically normal coronary arteries, no coronary-artery spasm, and myocardial lactate production after the administration of intracoronary papaverine. The implications of these results are unclear for other, similar patients in whom the lactate response to papaverine is unknown. What fraction of the patients with angina and normal coronary angiograms had myocardial lactate production after receiving intracoronary papaverine? It seems likely that a number of patients who had no lactate production might have…

Original languageEnglish
Pages (from-to)1739-1740
Number of pages2
JournalNew England Journal of Medicine
Issue number23
Publication statusPublished - Dec 2 1993

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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    Rossen, J. D., Agmon, Y., Gorlin, R., Abbott, E. C., Egashira, K., & Takeshita, A. (1993). Endothelial Dysfunction in Microvascular Angina. New England Journal of Medicine, 329(23), 1739-1740. https://doi.org/10.1056/NEJM199312023292316