Endothelin-1 increases the neuronal activity and augments the responses to glutamate in the NTS

Miwako Shihara, Yoshitaka Hirooka, Nobuaki Hori, Isamu Matsuo, Tatsuya Tagawa, Satoshi Suzuki, Norio Akaike, Akira Takeshita

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Abstract

The aims of this study were to determine 1) whether endothelin (ET)-1 affects the neuronal activity of the NTS neurons, 2) whether specific ET receptor antagonists affect the neuronal activity of the NTS neurons, and 3) whether ET-1 or ET receptor antagonists modulate the responses of the nucleus of the solitary tract (NTS) neurons to L-glutamate (Glu). The single-unit discharge was extracellularly recorded with a fine electrode from medulla brain slice preparations of rats. ET-1 and Glu were iontophoretically applied to the recorded neuron. Both ET-1 and Glu increased the neuronal activity. The ET(A) receptor antagonist BQ-123 attenuated the basal neuronal activity. ET-1 augmented the magnitude of the increases in the neuronal activity evoked by Glu, and these responses were antagonized by BQ-123. These studies suggest the following conclusions: 1) ET-1 increases the neuronal activity of the NTS neurons via ET(A) receptors, 2) endogenous ET plays a controlling role of the neuronal activity of NTS neurons, and 3) ET-1 augments the responses evoked by Glu, believed to be the neurotransmitter from the solitary tract, via ET(A) receptors. These results suggest that ET-1 facilitates synaptic transmission in the NTS.

Original languageEnglish
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume275
Issue number2 44-2
Publication statusPublished - Sep 2 1998

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Endothelin-1
Glutamic Acid
Neurons
Endothelin A Receptors
Endothelin-2
Solitary Nucleus
Synaptic Transmission
Neurotransmitter Agents
Electrodes
Brain

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

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Endothelin-1 increases the neuronal activity and augments the responses to glutamate in the NTS. / Shihara, Miwako; Hirooka, Yoshitaka; Hori, Nobuaki; Matsuo, Isamu; Tagawa, Tatsuya; Suzuki, Satoshi; Akaike, Norio; Takeshita, Akira.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 275, No. 2 44-2, 02.09.1998.

Research output: Contribution to journalArticle

Shihara, M, Hirooka, Y, Hori, N, Matsuo, I, Tagawa, T, Suzuki, S, Akaike, N & Takeshita, A 1998, 'Endothelin-1 increases the neuronal activity and augments the responses to glutamate in the NTS', American Journal of Physiology - Regulatory Integrative and Comparative Physiology, vol. 275, no. 2 44-2.
Shihara, Miwako ; Hirooka, Yoshitaka ; Hori, Nobuaki ; Matsuo, Isamu ; Tagawa, Tatsuya ; Suzuki, Satoshi ; Akaike, Norio ; Takeshita, Akira. / Endothelin-1 increases the neuronal activity and augments the responses to glutamate in the NTS. In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 1998 ; Vol. 275, No. 2 44-2.
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