TY - JOUR
T1 - Endothelin-1-induced prostaglandin E2 production
T2 - modulation of contractile response to endothelin-1 in porcine coronary artery
AU - Suzuki, Satoshi
AU - Suzuki, Akito
AU - Kajikuri, Junko
AU - Itoh, Takeo
N1 - Funding Information:
We are grateful to Prof. H. Kuriyama for his advice and to Dr. A.H. Weston (University of Manchester) for critical reading of the manuscript. This work was partly supported by a Grant-in-Aid from the Ministry of Education of Japan, the Ichiro Kanehara Foundation and the Japan Heart Foundation.
PY - 1992/6/24
Y1 - 1992/6/24
N2 - Endothelin-1 (ET-1, 1 nM) increased the release of prostaglandin E2 (PGE2) in endothelium-denuded smooth muscle strips of porcine coronary arteries. Indomethacin enhanced the amplitude of contraction induced by ET-1 and inhibited the stimulated release of PGE2. PGE2 (0.1-100 nM) attenuated the amplitude of contraction induced by 1 nM ET-1. These results suggest that in the smooth muscle of porcine coronary arteries, ET-1 increased the synthesis of PGE2, which functionally antagonizes the direct vasoconstrictor actions of ET-1.
AB - Endothelin-1 (ET-1, 1 nM) increased the release of prostaglandin E2 (PGE2) in endothelium-denuded smooth muscle strips of porcine coronary arteries. Indomethacin enhanced the amplitude of contraction induced by ET-1 and inhibited the stimulated release of PGE2. PGE2 (0.1-100 nM) attenuated the amplitude of contraction induced by 1 nM ET-1. These results suggest that in the smooth muscle of porcine coronary arteries, ET-1 increased the synthesis of PGE2, which functionally antagonizes the direct vasoconstrictor actions of ET-1.
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U2 - 10.1016/0014-2999(92)90517-8
DO - 10.1016/0014-2999(92)90517-8
M3 - Article
C2 - 1397025
AN - SCOPUS:0026724451
SN - 0014-2999
VL - 217
SP - 97
EP - 100
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 1
ER -