Endothelin-1 receptor antagonist prevents deterioration of left ventricular function and coronary flow reserve in brain-dead canine heart

Yasuhisa Oishi, Yosuke Nishimura, Yoshihisa Tanoue, Noriyoshi Kajihara, Ken Ichi Imasaka, Shigeki Morita, Hisataka Yasui

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Rapid hemodynamic deterioration is caused by induction of brain death, but the exact mechanism is still uncertain. The aim of this study was to investigate the contribution of endothelin-1 by using endothelin-1 receptor antagonist (TAK-044) in a canine brain-death model. Methods: Dogs were divided into 2 groups: (1) the TAK group, in which TAK-044 was intravenously injected 30 minutes before brain-death induction at a dose of 3 mg/kg; and (2) the control group. Brain death was induced by rapid inflation of a sub-durally placed balloon catheter. Left ventricular function and coronary flow reserve was compared between the 2 groups. Results: Brain death caused a transient hyperdynamic response followed by hemodynamic deterioration after 60 minutes in both groups. Left ventricular function, evaluated by the slope of the end-systolic pressure-volume relation was significantly decreased from 7.7 ± 0.6 to 3.7 ± 0.3 mm Hg/ml (p < 0.01) in the control group, but was not decreased in the TAK group (7.7 ± 0.8 to 7.3 ± 0.9 mm Hg/ml, p = 0.75). Coronary flow reserve, measured by direct injection of acetylcholine (3 μg) into the coronary artery, was significantly reduced at 60 minutes after brain death in the control group (264.8% to 176.6%, p < 0.01), but not in the TAK group (291.2% to 301.3%, p = 0.84). Exactly the same results were obtained when sodium nitroprusside (SNP; 100 μg) was administered. Conclusions: TAK-044 can prevent the deterioration of left ventricular function and coronary flow reserve that follows induction of brain death, suggesting that endothelin-1 could play an important role in hemodynamic deterioration by impairment of coronary microcirculation after brain death.

Original languageEnglish
Pages (from-to)1354-1361
Number of pages8
JournalJournal of Heart and Lung Transplantation
Volume24
Issue number9
DOIs
Publication statusPublished - Sep 1 2005

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Endothelin A Receptors
Brain Death
Left Ventricular Function
TAK 044
Canidae
Hemodynamics
Endothelin-1
Control Groups
Endothelin Receptor Antagonists
Economic Inflation
Nitroprusside
Microcirculation
Acetylcholine
Single Nucleotide Polymorphism
Coronary Vessels
Catheters
Dogs
Blood Pressure
Injections

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine
  • Transplantation

Cite this

Endothelin-1 receptor antagonist prevents deterioration of left ventricular function and coronary flow reserve in brain-dead canine heart. / Oishi, Yasuhisa; Nishimura, Yosuke; Tanoue, Yoshihisa; Kajihara, Noriyoshi; Imasaka, Ken Ichi; Morita, Shigeki; Yasui, Hisataka.

In: Journal of Heart and Lung Transplantation, Vol. 24, No. 9, 01.09.2005, p. 1354-1361.

Research output: Contribution to journalArticle

Oishi, Yasuhisa ; Nishimura, Yosuke ; Tanoue, Yoshihisa ; Kajihara, Noriyoshi ; Imasaka, Ken Ichi ; Morita, Shigeki ; Yasui, Hisataka. / Endothelin-1 receptor antagonist prevents deterioration of left ventricular function and coronary flow reserve in brain-dead canine heart. In: Journal of Heart and Lung Transplantation. 2005 ; Vol. 24, No. 9. pp. 1354-1361.
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AU - Tanoue, Yoshihisa

AU - Kajihara, Noriyoshi

AU - Imasaka, Ken Ichi

AU - Morita, Shigeki

AU - Yasui, Hisataka

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