Endothelium-dependent forearm vasodilation to acetylcholine but not to substance P is impaired in patients with heart failure

Yoshitaka Hirooka, T. Imaizumi, S. Harada, H. Masaki, M. Momohara, T. Tagawa, A. Takeshita

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

It has been shown that endothelium-dependent vasorelaxation in response to muscarinic stimulation is attenuated in patients as well as animals with heart failure. This study aimed to determine if endothelium-dependent forearm vasodilation evoked with substance P (SP) as well as acetylcholine (ACh) was impaired in patients with heart failure. Forearm blood flow was measured using a strain-gauge plethysmograph and forearm vascular responses to intra- arterial infusions of ACh, SP, or sodium nitroprusside (SNP) at graded doses were examined. The drugs caused the dose-dependent increases in forearm blood flow (FBF) and the decreases in forearm vascular resistance (FVR) in patients with heart failure as well as normal subjects. However, the percent decreases in FVR by ACh were less in patients with heart failure than in normal subjects (p < 0.01). In contrast, the percent decreases in FVR by SP or SNP did not differ between the two groups. These results suggest that endothelium-dependent vasodilation of forearm resistance vessels via muscarinic receptors is specifically impaired, whereas via SP receptors is preserved in patients with heart failure.

Original languageEnglish
JournalJournal of Cardiovascular Pharmacology
Volume20
Issue numberSUPPL. 12
DOIs
Publication statusPublished - Jan 1 1992

Fingerprint

Substance P
Forearm
Vasodilation
Acetylcholine
Endothelium
Heart Failure
Vascular Resistance
Nitroprusside
Neurokinin-1 Receptors
Intra Arterial Infusions
Muscarinic Receptors
Cholinergic Agents
Blood Vessels
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

Cite this

Endothelium-dependent forearm vasodilation to acetylcholine but not to substance P is impaired in patients with heart failure. / Hirooka, Yoshitaka; Imaizumi, T.; Harada, S.; Masaki, H.; Momohara, M.; Tagawa, T.; Takeshita, A.

In: Journal of Cardiovascular Pharmacology, Vol. 20, No. SUPPL. 12, 01.01.1992.

Research output: Contribution to journalArticle

Hirooka, Yoshitaka ; Imaizumi, T. ; Harada, S. ; Masaki, H. ; Momohara, M. ; Tagawa, T. ; Takeshita, A. / Endothelium-dependent forearm vasodilation to acetylcholine but not to substance P is impaired in patients with heart failure. In: Journal of Cardiovascular Pharmacology. 1992 ; Vol. 20, No. SUPPL. 12.
@article{5770bbae758e459ba28b4070656080cc,
title = "Endothelium-dependent forearm vasodilation to acetylcholine but not to substance P is impaired in patients with heart failure",
abstract = "It has been shown that endothelium-dependent vasorelaxation in response to muscarinic stimulation is attenuated in patients as well as animals with heart failure. This study aimed to determine if endothelium-dependent forearm vasodilation evoked with substance P (SP) as well as acetylcholine (ACh) was impaired in patients with heart failure. Forearm blood flow was measured using a strain-gauge plethysmograph and forearm vascular responses to intra- arterial infusions of ACh, SP, or sodium nitroprusside (SNP) at graded doses were examined. The drugs caused the dose-dependent increases in forearm blood flow (FBF) and the decreases in forearm vascular resistance (FVR) in patients with heart failure as well as normal subjects. However, the percent decreases in FVR by ACh were less in patients with heart failure than in normal subjects (p < 0.01). In contrast, the percent decreases in FVR by SP or SNP did not differ between the two groups. These results suggest that endothelium-dependent vasodilation of forearm resistance vessels via muscarinic receptors is specifically impaired, whereas via SP receptors is preserved in patients with heart failure.",
author = "Yoshitaka Hirooka and T. Imaizumi and S. Harada and H. Masaki and M. Momohara and T. Tagawa and A. Takeshita",
year = "1992",
month = "1",
day = "1",
doi = "10.1097/00005344-199204002-00063",
language = "English",
volume = "20",
journal = "Journal of Cardiovascular Pharmacology",
issn = "0160-2446",
publisher = "Lippincott Williams and Wilkins",
number = "SUPPL. 12",

}

TY - JOUR

T1 - Endothelium-dependent forearm vasodilation to acetylcholine but not to substance P is impaired in patients with heart failure

AU - Hirooka, Yoshitaka

AU - Imaizumi, T.

AU - Harada, S.

AU - Masaki, H.

AU - Momohara, M.

AU - Tagawa, T.

AU - Takeshita, A.

PY - 1992/1/1

Y1 - 1992/1/1

N2 - It has been shown that endothelium-dependent vasorelaxation in response to muscarinic stimulation is attenuated in patients as well as animals with heart failure. This study aimed to determine if endothelium-dependent forearm vasodilation evoked with substance P (SP) as well as acetylcholine (ACh) was impaired in patients with heart failure. Forearm blood flow was measured using a strain-gauge plethysmograph and forearm vascular responses to intra- arterial infusions of ACh, SP, or sodium nitroprusside (SNP) at graded doses were examined. The drugs caused the dose-dependent increases in forearm blood flow (FBF) and the decreases in forearm vascular resistance (FVR) in patients with heart failure as well as normal subjects. However, the percent decreases in FVR by ACh were less in patients with heart failure than in normal subjects (p < 0.01). In contrast, the percent decreases in FVR by SP or SNP did not differ between the two groups. These results suggest that endothelium-dependent vasodilation of forearm resistance vessels via muscarinic receptors is specifically impaired, whereas via SP receptors is preserved in patients with heart failure.

AB - It has been shown that endothelium-dependent vasorelaxation in response to muscarinic stimulation is attenuated in patients as well as animals with heart failure. This study aimed to determine if endothelium-dependent forearm vasodilation evoked with substance P (SP) as well as acetylcholine (ACh) was impaired in patients with heart failure. Forearm blood flow was measured using a strain-gauge plethysmograph and forearm vascular responses to intra- arterial infusions of ACh, SP, or sodium nitroprusside (SNP) at graded doses were examined. The drugs caused the dose-dependent increases in forearm blood flow (FBF) and the decreases in forearm vascular resistance (FVR) in patients with heart failure as well as normal subjects. However, the percent decreases in FVR by ACh were less in patients with heart failure than in normal subjects (p < 0.01). In contrast, the percent decreases in FVR by SP or SNP did not differ between the two groups. These results suggest that endothelium-dependent vasodilation of forearm resistance vessels via muscarinic receptors is specifically impaired, whereas via SP receptors is preserved in patients with heart failure.

UR - http://www.scopus.com/inward/record.url?scp=0027076661&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027076661&partnerID=8YFLogxK

U2 - 10.1097/00005344-199204002-00063

DO - 10.1097/00005344-199204002-00063

M3 - Article

VL - 20

JO - Journal of Cardiovascular Pharmacology

JF - Journal of Cardiovascular Pharmacology

SN - 0160-2446

IS - SUPPL. 12

ER -