Endothelium-dependent hyperpolarization (EDH) in hypertension: The role of endothelial ion channels

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

Upon stimulation with agonists and shear stress, the vascular endothelium of different vessels selectively releases several vasodilator factors such as nitric oxide and prostacyclin. In addition, vascular endothelial cells of many vessels regulate the contractility of the vascular smooth muscle cells through the generation of endothelium-dependent hyperpolarization (EDH). There is a general consensus that the opening of small- and intermediate-conductance Ca2+-activated K+ channels (SKCa and IKCa) is the initial mechanistic step for the generation of EDH. In animal models and humans, EDH and EDH-mediated relaxations are impaired during hypertension, and anti-hypertensive treatments restore such impairments. However, the underlying mechanisms of reduced EDH and its improvement by lowering blood pressure are poorly understood. Emerging evidence suggests that alterations of endothelial ion channels such as SKCa channels, inward rectifier K+ channels, Ca2+-activated Cl channels, and transient receptor potential vanilloid type 4 channels contribute to the impaired EDH during hypertension. In this review, we attempt to summarize the accumulating evidence regarding the pathophysiological role of endothelial ion channels, focusing on their relationship with EDH during hypertension.

Original languageEnglish
Article number315
JournalInternational journal of molecular sciences
Volume19
Issue number1
DOIs
Publication statusPublished - Jan 21 2018

Fingerprint

endothelium
hypertension
Ion Channels
Endothelium
Inwardly Rectifying Potassium Channel
Hypertension
Transient Receptor Potential Channels
Calcium-Activated Potassium Channels
Endothelial cells
Blood pressure
Nitric oxide
Ions
Epoprostenol
Vasodilator Agents
Antihypertensive Agents
Muscle
Shear stress
Nitric Oxide
Animals
Cells

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Endothelium-dependent hyperpolarization (EDH) in hypertension : The role of endothelial ion channels. / Goto, Kenichi; Ohtsubo, Toshio; Kitazono, Takanari.

In: International journal of molecular sciences, Vol. 19, No. 1, 315, 21.01.2018.

Research output: Contribution to journalReview article

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abstract = "Upon stimulation with agonists and shear stress, the vascular endothelium of different vessels selectively releases several vasodilator factors such as nitric oxide and prostacyclin. In addition, vascular endothelial cells of many vessels regulate the contractility of the vascular smooth muscle cells through the generation of endothelium-dependent hyperpolarization (EDH). There is a general consensus that the opening of small- and intermediate-conductance Ca2+-activated K+ channels (SKCa and IKCa) is the initial mechanistic step for the generation of EDH. In animal models and humans, EDH and EDH-mediated relaxations are impaired during hypertension, and anti-hypertensive treatments restore such impairments. However, the underlying mechanisms of reduced EDH and its improvement by lowering blood pressure are poorly understood. Emerging evidence suggests that alterations of endothelial ion channels such as SKCa channels, inward rectifier K+ channels, Ca2+-activated Cl– channels, and transient receptor potential vanilloid type 4 channels contribute to the impaired EDH during hypertension. In this review, we attempt to summarize the accumulating evidence regarding the pathophysiological role of endothelial ion channels, focusing on their relationship with EDH during hypertension.",
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