Engineering approach to irreversible electroporation

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Irreversible electroporation (IRE) is a new less-invasive therapy to treat abnormal tissues by applying a high voltage between the electrodes inserted in the tissue. Since the cell membrane exposed to the potential difference above a certain threshold is permanently disrupted, the IRE has a potential to necrotize cells without causing damage to the extracellular matrix (ECM), which is favorable for tissue regeneration during healing. However, determining an optimal condition of electrode configuration and applied pulses is critically important because an underdose of electrical pulses makes abnormal cells remain alive, while an overdose induces Joule heating of the tissue that causes thermal damage to the ECM. Studies from engineering point of view are therefore of great help to successful IRE. The present keynote lecture is a review of the authors' work associated with the IRE which includes a three-dimensional numerical simulation to estimate electric field and temperature distribution around electrodes, evaluation of cell destruction and thermal injury, detection of ultra-short temperature rise using a thermo-responsive ink, detection of denaturation of protein using Raman spectroscopy, and the IRE experiment with threedimensional cell culture model.

Original languageEnglish
Title of host publicationProceedings of the 15th International Heat Transfer Conference, IHTC 2014
PublisherBegell House Inc.
Publication statusPublished - 2014
Event15th International Heat Transfer Conference, IHTC 2014 - Kyoto, Japan
Duration: Aug 10 2014Aug 15 2014

Other

Other15th International Heat Transfer Conference, IHTC 2014
CountryJapan
CityKyoto
Period8/10/148/15/14

Fingerprint

engineering
Tissue
Electrodes
electrodes
Tissue regeneration
Denaturation
Joule heating
cells
Cell membranes
damage
Cell culture
Ink
Raman spectroscopy
biopolymer denaturation
lectures
healing
inks
Temperature distribution
matrices
pulses

All Science Journal Classification (ASJC) codes

  • Mechanical Engineering
  • Condensed Matter Physics

Cite this

Takamatsu, H., & Kurata, K. (2014). Engineering approach to irreversible electroporation. In Proceedings of the 15th International Heat Transfer Conference, IHTC 2014 Begell House Inc..

Engineering approach to irreversible electroporation. / Takamatsu, Hiroshi; Kurata, Kosaku.

Proceedings of the 15th International Heat Transfer Conference, IHTC 2014. Begell House Inc., 2014.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Takamatsu, H & Kurata, K 2014, Engineering approach to irreversible electroporation. in Proceedings of the 15th International Heat Transfer Conference, IHTC 2014. Begell House Inc., 15th International Heat Transfer Conference, IHTC 2014, Kyoto, Japan, 8/10/14.
Takamatsu H, Kurata K. Engineering approach to irreversible electroporation. In Proceedings of the 15th International Heat Transfer Conference, IHTC 2014. Begell House Inc. 2014
Takamatsu, Hiroshi ; Kurata, Kosaku. / Engineering approach to irreversible electroporation. Proceedings of the 15th International Heat Transfer Conference, IHTC 2014. Begell House Inc., 2014.
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