TY - GEN
T1 - Enhanced cell stiffness evaluation by two-phase decomposition
AU - Tsai, Chia Hung Dylan
AU - Kaneko, Makoto
AU - Sakuma, Shinya
AU - Arai, Fumihito
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2012
Y1 - 2012
N2 - This work proposes an enhanced method for cell stiffness evaluation by eliminating the effect from cell viscosity. While the passing time of cell through a μ-channel is used for evaluating cell stiffness in the conventional method, the time includes both the effects of cell stiffness and cell viscosity. The key idea is that we separate the cell motion inside a μ-channel into two phases, the phases of deformation and constant velocity. We evaluate the cell stiffness by focusing on the cell motion in the phase of constant velocity. The results of experimental study are presented and discussed.
AB - This work proposes an enhanced method for cell stiffness evaluation by eliminating the effect from cell viscosity. While the passing time of cell through a μ-channel is used for evaluating cell stiffness in the conventional method, the time includes both the effects of cell stiffness and cell viscosity. The key idea is that we separate the cell motion inside a μ-channel into two phases, the phases of deformation and constant velocity. We evaluate the cell stiffness by focusing on the cell motion in the phase of constant velocity. The results of experimental study are presented and discussed.
UR - http://www.scopus.com/inward/record.url?scp=84887288149&partnerID=8YFLogxK
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M3 - Conference contribution
AN - SCOPUS:84887288149
SN - 9780979806452
T3 - Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
SP - 1009
EP - 1011
BT - Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
PB - Chemical and Biological Microsystems Society
T2 - 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
Y2 - 28 October 2012 through 1 November 2012
ER -