Enhanced coexpression of thioredoxin and high mobility group protein 1 genes in human hepatocellular carcinoma and the possible association with decreased sensitivity to cisplatin

Naoyuki Kawahara; Toshiya Tanaka; Akira Yokomizo; Hiroki Nanri; Mayumi Ono; Morimasa Wada; Kimitoshi Kohno; Kenji Takenaka; Keizo Sugimachi; Michihiko Kuwano

Enhanced coexpression of thioredoxin and high mobility group protein 1 genes in human hepatocellular carcinoma and the possible association with decreased sensitivity to cisplatin

Naoyuki Kawahara, Toshiya Tanaka, Akira Yokomizo, Hiroki Nanri, Mayumi Ono, Morimasa Wada, Kimitoshi Kohno, Kenji Takenaka, Keizo Sugimachi, Michihiko Kuwano

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Abstract

Thioredoxin (TRX), a disulfide-reducing intracellular protein, functions as a cellular defense mechanism against oxidative stress. In this study, we asked whether expression of TRX, glutathione-thiol transferase π, and high mobility group protein 1 (HMG-I) genes is enhanced in human hepatocellular carcinoma and whether expression of these genes is associated with sensitivity to cisplatin. Both TRX and HMG-1 were co-overexpressed in almost all cancerous lesions in comparison to normal tissue in surgically resected hepatocellular carcinomas of 20 patients. Tumor sensitivity to cisplatin [cis-diamminedichloroplatinum (II)], but not to mitomycin C or doxorubicin, correlated with mRNA levels of TRX in cancer tissue. TRX and HMG-1 may be useful tumor markers, and TRX might he also a useful marker for sensitivity to cisplatin in human hepatocellular carcinomas.

Original language	English
Pages (from-to)	5330-5333
Number of pages	4
Journal	Cancer Research
Volume	56
Issue number	23
Publication status	Published - Dec 1 1996

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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Enhanced coexpression of thioredoxin and high mobility group protein 1 genes in human hepatocellular carcinoma and the possible association with decreased sensitivity to cisplatin. / Kawahara, Naoyuki; Tanaka, Toshiya; Yokomizo, Akira et al.
In: Cancer Research, Vol. 56, No. 23, 01.12.1996, p. 5330-5333.

Research output: Contribution to journal › Article › peer-review

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abstract = "Thioredoxin (TRX), a disulfide-reducing intracellular protein, functions as a cellular defense mechanism against oxidative stress. In this study, we asked whether expression of TRX, glutathione-thiol transferase π, and high mobility group protein 1 (HMG-I) genes is enhanced in human hepatocellular carcinoma and whether expression of these genes is associated with sensitivity to cisplatin. Both TRX and HMG-1 were co-overexpressed in almost all cancerous lesions in comparison to normal tissue in surgically resected hepatocellular carcinomas of 20 patients. Tumor sensitivity to cisplatin [cis-diamminedichloroplatinum (II)], but not to mitomycin C or doxorubicin, correlated with mRNA levels of TRX in cancer tissue. TRX and HMG-1 may be useful tumor markers, and TRX might he also a useful marker for sensitivity to cisplatin in human hepatocellular carcinomas.",

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AU - Tanaka, Toshiya

AU - Yokomizo, Akira

AU - Nanri, Hiroki

AU - Ono, Mayumi

AU - Wada, Morimasa

AU - Kohno, Kimitoshi

AU - Takenaka, Kenji

AU - Sugimachi, Keizo

AU - Kuwano, Michihiko

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AB - Thioredoxin (TRX), a disulfide-reducing intracellular protein, functions as a cellular defense mechanism against oxidative stress. In this study, we asked whether expression of TRX, glutathione-thiol transferase π, and high mobility group protein 1 (HMG-I) genes is enhanced in human hepatocellular carcinoma and whether expression of these genes is associated with sensitivity to cisplatin. Both TRX and HMG-1 were co-overexpressed in almost all cancerous lesions in comparison to normal tissue in surgically resected hepatocellular carcinomas of 20 patients. Tumor sensitivity to cisplatin [cis-diamminedichloroplatinum (II)], but not to mitomycin C or doxorubicin, correlated with mRNA levels of TRX in cancer tissue. TRX and HMG-1 may be useful tumor markers, and TRX might he also a useful marker for sensitivity to cisplatin in human hepatocellular carcinomas.

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Enhanced coexpression of thioredoxin and high mobility group protein 1 genes in human hepatocellular carcinoma and the possible association with decreased sensitivity to cisplatin

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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