TY - JOUR
T1 - Enhanced Echo Intensity of Skeletal Muscle Is Associated With Exercise Intolerance in Patients With Heart Failure
AU - Nakano, Ippei
AU - Hori, Hiroaki
AU - Fukushima, Arata
AU - Yokota, Takashi
AU - Kinugawa, Shintaro
AU - Takada, Shingo
AU - Yamanashi, Katsuma
AU - Obata, Yoshikuni
AU - Kitaura, Yasuyuki
AU - Kakutani, Naoya
AU - Abe, Takahiro
AU - Anzai, Toshihisa
N1 - Funding Information:
Funding: This study was supported by grants from the Clinical Research (Medical Profession) of the Japanese Circulation Society (2017) and the Japanese Association of Cardiac Rehabilitation, Takeda Science Foundation, the Japan Ministry of Education, Science, and Culture (nos. 26350879, 15K09115, 17K10137), and the Center of Innovation Program from the Japan Science and Technology Agency.
Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2020/8
Y1 - 2020/8
N2 - Background: Skeletal muscle is quantitatively and qualitatively impaired in patients with heart failure (HF), which is closely linked to lowered exercise capacity. Ultrasonography (US) for skeletal muscle has emerged as a useful, noninvasive tool to evaluate muscle quality and quantity. Here we investigated whether muscle quality based on US-derived echo intensity (EI) is associated with exercise capacity in patients with HF. Methods and Results: Fifty-eight patients with HF (61 ± 12 years) and 28 control subjects (58 ± 14 years) were studied. The quadriceps femoris echo intensity (QEI) was significantly higher and the quadriceps femoris muscle thickness (QMT) was significantly lower in the patients with HF than the controls (88.3 ± 13.4 vs 81.1 ± 7.5, P=.010; 5.21 ± 1.10 vs 6.54 ±1.34 cm, P<.001, respectively). By univariate analysis, QEI was significantly correlated with age, peak oxygen uptake (VO2), and New York Heart Association class in the HF group. A multivariable analysis revealed that the QEI was independently associated with peak VO2 after adjustment for age, gender, body mass index, and QMT: β-coefficient = −11.80, 95%CI (−20.73, −2.86), P=.011. Conclusion: Enhanced EI in skeletal muscle was independently associated with lowered exercise capacity in HF. The measurement of EI is low-cost, easily accessible, and suitable for assessment of HF-related alterations in skeletal muscle quality.
AB - Background: Skeletal muscle is quantitatively and qualitatively impaired in patients with heart failure (HF), which is closely linked to lowered exercise capacity. Ultrasonography (US) for skeletal muscle has emerged as a useful, noninvasive tool to evaluate muscle quality and quantity. Here we investigated whether muscle quality based on US-derived echo intensity (EI) is associated with exercise capacity in patients with HF. Methods and Results: Fifty-eight patients with HF (61 ± 12 years) and 28 control subjects (58 ± 14 years) were studied. The quadriceps femoris echo intensity (QEI) was significantly higher and the quadriceps femoris muscle thickness (QMT) was significantly lower in the patients with HF than the controls (88.3 ± 13.4 vs 81.1 ± 7.5, P=.010; 5.21 ± 1.10 vs 6.54 ±1.34 cm, P<.001, respectively). By univariate analysis, QEI was significantly correlated with age, peak oxygen uptake (VO2), and New York Heart Association class in the HF group. A multivariable analysis revealed that the QEI was independently associated with peak VO2 after adjustment for age, gender, body mass index, and QMT: β-coefficient = −11.80, 95%CI (−20.73, −2.86), P=.011. Conclusion: Enhanced EI in skeletal muscle was independently associated with lowered exercise capacity in HF. The measurement of EI is low-cost, easily accessible, and suitable for assessment of HF-related alterations in skeletal muscle quality.
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U2 - 10.1016/j.cardfail.2019.09.001
DO - 10.1016/j.cardfail.2019.09.001
M3 - Article
C2 - 31533068
AN - SCOPUS:85073151223
SN - 1071-9164
VL - 26
SP - 685
EP - 693
JO - Journal of Cardiac Failure
JF - Journal of Cardiac Failure
IS - 8
ER -