TY - JOUR
T1 - Enhanced intraarticular free radical reactions in adjuvant arthritis rats
AU - Yamada, Ken Ichi
AU - Nakamura, Toshitaka
AU - Utsumi, Hideo
N1 - Funding Information:
This work is supported in part by Grants-in-Aid of Scientific Research, for Research in Priority Areas, for Cooperative Research, for General Science Research, and for Developmental Scientific Research from the Ministry of Education, Science, Sports and Culture of Japan.
PY - 2006/5
Y1 - 2006/5
N2 - One of the reasons of rheumatoid arthritis (RA) development is widely recognized the relation of free radical reactions in tissue injuries. The aim of this study was to evaluate the location where in vivo free radical reactions was enhanced in adjuvant arthritis (AA) model rats using in vivo electron spin resonance (ESR)/nitroxyl spin probe technique. The signal decay after intravenous injection of spin probe was enhanced in AA than that in control and suppressed by the pre-treatment of dexamethasone (DXT). Interestingly, the decay in joint cavity occurred prior to paw swelling of AA and suppressed by a simultaneous injection of free radical scavengers, indicating that the enhancement of free radical reactions in joint cavity of AA rats. This technique would be useful tool to determine the location of the enhanced free radical reactions and evaluate the activity of antioxidant medicine with non-invasive real-time measurement.
AB - One of the reasons of rheumatoid arthritis (RA) development is widely recognized the relation of free radical reactions in tissue injuries. The aim of this study was to evaluate the location where in vivo free radical reactions was enhanced in adjuvant arthritis (AA) model rats using in vivo electron spin resonance (ESR)/nitroxyl spin probe technique. The signal decay after intravenous injection of spin probe was enhanced in AA than that in control and suppressed by the pre-treatment of dexamethasone (DXT). Interestingly, the decay in joint cavity occurred prior to paw swelling of AA and suppressed by a simultaneous injection of free radical scavengers, indicating that the enhancement of free radical reactions in joint cavity of AA rats. This technique would be useful tool to determine the location of the enhanced free radical reactions and evaluate the activity of antioxidant medicine with non-invasive real-time measurement.
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U2 - 10.1080/10715760500440536
DO - 10.1080/10715760500440536
M3 - Article
C2 - 16551571
AN - SCOPUS:33645103439
SN - 1071-5762
VL - 40
SP - 455
EP - 460
JO - Free Radical Research
JF - Free Radical Research
IS - 5
ER -