Enhanced resistance to herpes simplex virus type 1 infection in transgenic mice expressing a soluble form of herpesvirus entry mediator

Etsuro Ono, Saori Yoshino, Keiko Amagai, Satoshi Taharaguchi, Chiemi Kimura, Junko Morimoto, Manabu Inobe, Tomoko Uenishi, Toshimitsu Uede

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20 Citations (Scopus)

Abstract

Herpesvirus entry mediator (HVEM) is a member of the tumor necrosis factor (TNF) receptor family used as a cellular receptor by virion glycoprotein D (gD) of herpes simplex virus (HSV). Both human and mouse forms of HVEM can mediate entry of HSV-1 but have no entry activity for pseudorabies virus (PRV). To assess the antiviral potential of HVEM in vivo, three transgenic mouse lines expressing a soluble form of HVEM (HVEMIg) consisting of an extracellular domain of murine HVEM and the Fc portion of human IgG1 were generated. All of the transgenic mouse lines showed marked resistance to HSV-1 infection when the mice were challenged intraperitoneally with HSV-1, but not to PRV infection. The present results demonstrate that HVEMIg is able to exert a significant antiviral effect against HSV-1 infection in vivo.

Original languageEnglish
Pages (from-to)267-275
Number of pages9
JournalVirology
Volume320
Issue number2
DOIs
Publication statusPublished - Mar 15 2004
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Virology

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    Ono, E., Yoshino, S., Amagai, K., Taharaguchi, S., Kimura, C., Morimoto, J., Inobe, M., Uenishi, T., & Uede, T. (2004). Enhanced resistance to herpes simplex virus type 1 infection in transgenic mice expressing a soluble form of herpesvirus entry mediator. Virology, 320(2), 267-275. https://doi.org/10.1016/j.virol.2003.11.031