Enhanced resistance to herpes simplex virus type 1 infection in transgenic mice expressing a soluble form of herpesvirus entry mediator

Etsuro Ono, Saori Yoshino, Keiko Amagai, Satoshi Taharaguchi, Chiemi Kimura, Junko Morimoto, Manabu Inobe, Tomoko Uenishi, Toshimitsu Uede

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Herpesvirus entry mediator (HVEM) is a member of the tumor necrosis factor (TNF) receptor family used as a cellular receptor by virion glycoprotein D (gD) of herpes simplex virus (HSV). Both human and mouse forms of HVEM can mediate entry of HSV-1 but have no entry activity for pseudorabies virus (PRV). To assess the antiviral potential of HVEM in vivo, three transgenic mouse lines expressing a soluble form of HVEM (HVEMIg) consisting of an extracellular domain of murine HVEM and the Fc portion of human IgG1 were generated. All of the transgenic mouse lines showed marked resistance to HSV-1 infection when the mice were challenged intraperitoneally with HSV-1, but not to PRV infection. The present results demonstrate that HVEMIg is able to exert a significant antiviral effect against HSV-1 infection in vivo.

Original languageEnglish
Pages (from-to)267-275
Number of pages9
JournalVirology
Volume320
Issue number2
DOIs
Publication statusPublished - Mar 15 2004

Fingerprint

Receptors, Tumor Necrosis Factor, Member 14
Human Herpesvirus 1
Virus Diseases
Transgenic Mice
Suid Herpesvirus 1
Antiviral Agents
Tumor Necrosis Factor Receptors
Simplexvirus
Virion
Glycoproteins
Immunoglobulin G

All Science Journal Classification (ASJC) codes

  • Virology

Cite this

Enhanced resistance to herpes simplex virus type 1 infection in transgenic mice expressing a soluble form of herpesvirus entry mediator. / Ono, Etsuro; Yoshino, Saori; Amagai, Keiko; Taharaguchi, Satoshi; Kimura, Chiemi; Morimoto, Junko; Inobe, Manabu; Uenishi, Tomoko; Uede, Toshimitsu.

In: Virology, Vol. 320, No. 2, 15.03.2004, p. 267-275.

Research output: Contribution to journalArticle

Ono, E, Yoshino, S, Amagai, K, Taharaguchi, S, Kimura, C, Morimoto, J, Inobe, M, Uenishi, T & Uede, T 2004, 'Enhanced resistance to herpes simplex virus type 1 infection in transgenic mice expressing a soluble form of herpesvirus entry mediator', Virology, vol. 320, no. 2, pp. 267-275. https://doi.org/10.1016/j.virol.2003.11.031
Ono, Etsuro ; Yoshino, Saori ; Amagai, Keiko ; Taharaguchi, Satoshi ; Kimura, Chiemi ; Morimoto, Junko ; Inobe, Manabu ; Uenishi, Tomoko ; Uede, Toshimitsu. / Enhanced resistance to herpes simplex virus type 1 infection in transgenic mice expressing a soluble form of herpesvirus entry mediator. In: Virology. 2004 ; Vol. 320, No. 2. pp. 267-275.
@article{72323e66e06f4b99a28371c4b58bb08c,
title = "Enhanced resistance to herpes simplex virus type 1 infection in transgenic mice expressing a soluble form of herpesvirus entry mediator",
abstract = "Herpesvirus entry mediator (HVEM) is a member of the tumor necrosis factor (TNF) receptor family used as a cellular receptor by virion glycoprotein D (gD) of herpes simplex virus (HSV). Both human and mouse forms of HVEM can mediate entry of HSV-1 but have no entry activity for pseudorabies virus (PRV). To assess the antiviral potential of HVEM in vivo, three transgenic mouse lines expressing a soluble form of HVEM (HVEMIg) consisting of an extracellular domain of murine HVEM and the Fc portion of human IgG1 were generated. All of the transgenic mouse lines showed marked resistance to HSV-1 infection when the mice were challenged intraperitoneally with HSV-1, but not to PRV infection. The present results demonstrate that HVEMIg is able to exert a significant antiviral effect against HSV-1 infection in vivo.",
author = "Etsuro Ono and Saori Yoshino and Keiko Amagai and Satoshi Taharaguchi and Chiemi Kimura and Junko Morimoto and Manabu Inobe and Tomoko Uenishi and Toshimitsu Uede",
year = "2004",
month = "3",
day = "15",
doi = "10.1016/j.virol.2003.11.031",
language = "English",
volume = "320",
pages = "267--275",
journal = "Virology",
issn = "0042-6822",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Enhanced resistance to herpes simplex virus type 1 infection in transgenic mice expressing a soluble form of herpesvirus entry mediator

AU - Ono, Etsuro

AU - Yoshino, Saori

AU - Amagai, Keiko

AU - Taharaguchi, Satoshi

AU - Kimura, Chiemi

AU - Morimoto, Junko

AU - Inobe, Manabu

AU - Uenishi, Tomoko

AU - Uede, Toshimitsu

PY - 2004/3/15

Y1 - 2004/3/15

N2 - Herpesvirus entry mediator (HVEM) is a member of the tumor necrosis factor (TNF) receptor family used as a cellular receptor by virion glycoprotein D (gD) of herpes simplex virus (HSV). Both human and mouse forms of HVEM can mediate entry of HSV-1 but have no entry activity for pseudorabies virus (PRV). To assess the antiviral potential of HVEM in vivo, three transgenic mouse lines expressing a soluble form of HVEM (HVEMIg) consisting of an extracellular domain of murine HVEM and the Fc portion of human IgG1 were generated. All of the transgenic mouse lines showed marked resistance to HSV-1 infection when the mice were challenged intraperitoneally with HSV-1, but not to PRV infection. The present results demonstrate that HVEMIg is able to exert a significant antiviral effect against HSV-1 infection in vivo.

AB - Herpesvirus entry mediator (HVEM) is a member of the tumor necrosis factor (TNF) receptor family used as a cellular receptor by virion glycoprotein D (gD) of herpes simplex virus (HSV). Both human and mouse forms of HVEM can mediate entry of HSV-1 but have no entry activity for pseudorabies virus (PRV). To assess the antiviral potential of HVEM in vivo, three transgenic mouse lines expressing a soluble form of HVEM (HVEMIg) consisting of an extracellular domain of murine HVEM and the Fc portion of human IgG1 were generated. All of the transgenic mouse lines showed marked resistance to HSV-1 infection when the mice were challenged intraperitoneally with HSV-1, but not to PRV infection. The present results demonstrate that HVEMIg is able to exert a significant antiviral effect against HSV-1 infection in vivo.

UR - http://www.scopus.com/inward/record.url?scp=1542315570&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1542315570&partnerID=8YFLogxK

U2 - 10.1016/j.virol.2003.11.031

DO - 10.1016/j.virol.2003.11.031

M3 - Article

C2 - 15016549

AN - SCOPUS:1542315570

VL - 320

SP - 267

EP - 275

JO - Virology

JF - Virology

SN - 0042-6822

IS - 2

ER -