Abstract
We have investigated the effect of glucose on the release of endothelin-1-like immunoreactivity (ET-l-LI) from cultured bovine aortic endothelial cells. Elevation of glucose concentrations in cultured media from 5.5 to 11.1 or 22.2 mM significantly stimulated ET-1-LI release from cultured endothelial cells. An aldose reductase inhibitor did not affect the high glucose-induced ET-1-LI release, These findings suggest the possibility that hyperglycemia in diabetic patients enhances ET-1-LI release at the local site of vascular endothelium. which might be involved in the developments of vascular complications and atherosclerosis.
| Original language | English |
|---|---|
| Pages (from-to) | 16-18 |
| Number of pages | 3 |
| Journal | FEBS Letters |
| Volume | 267 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jul 2 1990 |
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All Science Journal Classification (ASJC) codes
- Biophysics
- Structural Biology
- Biochemistry
- Molecular Biology
- Genetics
- Cell Biology
Cite this
Enhanced secretion of endothelin-1 by elevated glucose levels from cultured bovine aortic endothelial cells. / Yamauchi, Teruaki; Ohnaka, Keizo; Takayanagi, Ryoichi; Umeda, Fumio; Nawata, Hajime.
In: FEBS Letters, Vol. 267, No. 1, 02.07.1990, p. 16-18.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Enhanced secretion of endothelin-1 by elevated glucose levels from cultured bovine aortic endothelial cells
AU - Yamauchi, Teruaki
AU - Ohnaka, Keizo
AU - Takayanagi, Ryoichi
AU - Umeda, Fumio
AU - Nawata, Hajime
PY - 1990/7/2
Y1 - 1990/7/2
N2 - We have investigated the effect of glucose on the release of endothelin-1-like immunoreactivity (ET-l-LI) from cultured bovine aortic endothelial cells. Elevation of glucose concentrations in cultured media from 5.5 to 11.1 or 22.2 mM significantly stimulated ET-1-LI release from cultured endothelial cells. An aldose reductase inhibitor did not affect the high glucose-induced ET-1-LI release, These findings suggest the possibility that hyperglycemia in diabetic patients enhances ET-1-LI release at the local site of vascular endothelium. which might be involved in the developments of vascular complications and atherosclerosis.
AB - We have investigated the effect of glucose on the release of endothelin-1-like immunoreactivity (ET-l-LI) from cultured bovine aortic endothelial cells. Elevation of glucose concentrations in cultured media from 5.5 to 11.1 or 22.2 mM significantly stimulated ET-1-LI release from cultured endothelial cells. An aldose reductase inhibitor did not affect the high glucose-induced ET-1-LI release, These findings suggest the possibility that hyperglycemia in diabetic patients enhances ET-1-LI release at the local site of vascular endothelium. which might be involved in the developments of vascular complications and atherosclerosis.
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UR - http://www.scopus.com/inward/citedby.url?scp=0025369479&partnerID=8YFLogxK
U2 - 10.1016/0014-5793(90)80276-O
DO - 10.1016/0014-5793(90)80276-O
M3 - Article
C2 - 2114322
AN - SCOPUS:0025369479
VL - 267
SP - 16
EP - 18
JO - FEBS Letters
JF - FEBS Letters
SN - 0014-5793
IS - 1
ER -