Enhanced secretion of endothelin-1 by elevated glucose levels from cultured bovine aortic endothelial cells

Teruaki Yamauchi; Keizo Ohnaka; Ryoichi Takayanagi; Fumio Umeda; Hajime Nawata

doi:10.1016/0014-5793(90)80276-O

Enhanced secretion of endothelin-1 by elevated glucose levels from cultured bovine aortic endothelial cells

Teruaki Yamauchi, Keizo Ohnaka, Ryoichi Takayanagi, Fumio Umeda, Hajime Nawata

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Abstract

We have investigated the effect of glucose on the release of endothelin-1-like immunoreactivity (ET-l-LI) from cultured bovine aortic endothelial cells. Elevation of glucose concentrations in cultured media from 5.5 to 11.1 or 22.2 mM significantly stimulated ET-1-LI release from cultured endothelial cells. An aldose reductase inhibitor did not affect the high glucose-induced ET-1-LI release, These findings suggest the possibility that hyperglycemia in diabetic patients enhances ET-1-LI release at the local site of vascular endothelium. which might be involved in the developments of vascular complications and atherosclerosis.

Original language	English
Pages (from-to)	16-18
Number of pages	3
Journal	FEBS Letters
Volume	267
Issue number	1
DOIs	https://doi.org/10.1016/0014-5793(90)80276-O
Publication status	Published - Jul 2 1990

All Science Journal Classification (ASJC) codes

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/0014-5793(90)80276-O

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abstract = "We have investigated the effect of glucose on the release of endothelin-1-like immunoreactivity (ET-l-LI) from cultured bovine aortic endothelial cells. Elevation of glucose concentrations in cultured media from 5.5 to 11.1 or 22.2 mM significantly stimulated ET-1-LI release from cultured endothelial cells. An aldose reductase inhibitor did not affect the high glucose-induced ET-1-LI release, These findings suggest the possibility that hyperglycemia in diabetic patients enhances ET-1-LI release at the local site of vascular endothelium. which might be involved in the developments of vascular complications and atherosclerosis.",

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AU - Umeda, Fumio

AU - Nawata, Hajime

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Y1 - 1990/7/2

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Enhanced secretion of endothelin-1 by elevated glucose levels from cultured bovine aortic endothelial cells

Abstract

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