Enhanced secretion of endothelin-1 by elevated glucose levels from cultured bovine aortic endothelial cells

Teruaki Yamauchi, Keizo Ohnaka, Ryoichi Takayanagi, Fumio Umeda, Hajime Nawata

Research output: Contribution to journalArticle

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Abstract

We have investigated the effect of glucose on the release of endothelin-1-like immunoreactivity (ET-l-LI) from cultured bovine aortic endothelial cells. Elevation of glucose concentrations in cultured media from 5.5 to 11.1 or 22.2 mM significantly stimulated ET-1-LI release from cultured endothelial cells. An aldose reductase inhibitor did not affect the high glucose-induced ET-1-LI release, These findings suggest the possibility that hyperglycemia in diabetic patients enhances ET-1-LI release at the local site of vascular endothelium. which might be involved in the developments of vascular complications and atherosclerosis.

Original languageEnglish
Pages (from-to)16-18
Number of pages3
JournalFEBS Letters
Volume267
Issue number1
DOIs
Publication statusPublished - Jul 2 1990

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Endothelial cells
Endothelin-1
Endothelial Cells
Glucose
Aldehyde Reductase
Vascular Endothelium
Hyperglycemia
Blood Vessels
Cultured Cells
Atherosclerosis

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Enhanced secretion of endothelin-1 by elevated glucose levels from cultured bovine aortic endothelial cells. / Yamauchi, Teruaki; Ohnaka, Keizo; Takayanagi, Ryoichi; Umeda, Fumio; Nawata, Hajime.

In: FEBS Letters, Vol. 267, No. 1, 02.07.1990, p. 16-18.

Research output: Contribution to journalArticle

Yamauchi, Teruaki ; Ohnaka, Keizo ; Takayanagi, Ryoichi ; Umeda, Fumio ; Nawata, Hajime. / Enhanced secretion of endothelin-1 by elevated glucose levels from cultured bovine aortic endothelial cells. In: FEBS Letters. 1990 ; Vol. 267, No. 1. pp. 16-18.
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