Enhanced secretion of endothelin-1 by elevated glucose levels from cultured bovine aortic endothelial cells

Teruaki Yamauchi; Keizo Ohnaka; Ryoichi Takayanagi; Fumio Umeda; Hajime Nawata

doi:10.1016/0014-5793(90)80276-O

Enhanced secretion of endothelin-1 by elevated glucose levels from cultured bovine aortic endothelial cells

Teruaki Yamauchi, Keizo Ohnaka, Ryoichi Takayanagi, Fumio Umeda, Hajime Nawata

Advanced Medical Intiatives

Research output: Contribution to journal › Article › peer-review

169 Citations (Scopus)

Abstract

We have investigated the effect of glucose on the release of endothelin-1-like immunoreactivity (ET-l-LI) from cultured bovine aortic endothelial cells. Elevation of glucose concentrations in cultured media from 5.5 to 11.1 or 22.2 mM significantly stimulated ET-1-LI release from cultured endothelial cells. An aldose reductase inhibitor did not affect the high glucose-induced ET-1-LI release, These findings suggest the possibility that hyperglycemia in diabetic patients enhances ET-1-LI release at the local site of vascular endothelium. which might be involved in the developments of vascular complications and atherosclerosis.

Original language	English
Pages (from-to)	16-18
Number of pages	3
Journal	FEBS Letters
Volume	267
Issue number	1
DOIs	https://doi.org/10.1016/0014-5793(90)80276-O
Publication status	Published - Jul 2 1990

All Science Journal Classification (ASJC) codes

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

Access to Document

10.1016/0014-5793(90)80276-O

Fingerprint Dive into the research topics of 'Enhanced secretion of endothelin-1 by elevated glucose levels from cultured bovine aortic endothelial cells'. Together they form a unique fingerprint.

Cite this

@article{a0877dab663d4f169d4bda99a882f86c,

title = "Enhanced secretion of endothelin-1 by elevated glucose levels from cultured bovine aortic endothelial cells",

abstract = "We have investigated the effect of glucose on the release of endothelin-1-like immunoreactivity (ET-l-LI) from cultured bovine aortic endothelial cells. Elevation of glucose concentrations in cultured media from 5.5 to 11.1 or 22.2 mM significantly stimulated ET-1-LI release from cultured endothelial cells. An aldose reductase inhibitor did not affect the high glucose-induced ET-1-LI release, These findings suggest the possibility that hyperglycemia in diabetic patients enhances ET-1-LI release at the local site of vascular endothelium. which might be involved in the developments of vascular complications and atherosclerosis.",

author = "Teruaki Yamauchi and Keizo Ohnaka and Ryoichi Takayanagi and Fumio Umeda and Hajime Nawata",

year = "1990",

month = jul,

day = "2",

doi = "10.1016/0014-5793(90)80276-O",

language = "English",

volume = "267",

pages = "16--18",

journal = "FEBS Letters",

issn = "0014-5793",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Enhanced secretion of endothelin-1 by elevated glucose levels from cultured bovine aortic endothelial cells

AU - Yamauchi, Teruaki

AU - Ohnaka, Keizo

AU - Takayanagi, Ryoichi

AU - Umeda, Fumio

AU - Nawata, Hajime

PY - 1990/7/2

Y1 - 1990/7/2

N2 - We have investigated the effect of glucose on the release of endothelin-1-like immunoreactivity (ET-l-LI) from cultured bovine aortic endothelial cells. Elevation of glucose concentrations in cultured media from 5.5 to 11.1 or 22.2 mM significantly stimulated ET-1-LI release from cultured endothelial cells. An aldose reductase inhibitor did not affect the high glucose-induced ET-1-LI release, These findings suggest the possibility that hyperglycemia in diabetic patients enhances ET-1-LI release at the local site of vascular endothelium. which might be involved in the developments of vascular complications and atherosclerosis.

AB - We have investigated the effect of glucose on the release of endothelin-1-like immunoreactivity (ET-l-LI) from cultured bovine aortic endothelial cells. Elevation of glucose concentrations in cultured media from 5.5 to 11.1 or 22.2 mM significantly stimulated ET-1-LI release from cultured endothelial cells. An aldose reductase inhibitor did not affect the high glucose-induced ET-1-LI release, These findings suggest the possibility that hyperglycemia in diabetic patients enhances ET-1-LI release at the local site of vascular endothelium. which might be involved in the developments of vascular complications and atherosclerosis.

UR - http://www.scopus.com/inward/record.url?scp=0025369479&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025369479&partnerID=8YFLogxK

U2 - 10.1016/0014-5793(90)80276-O

DO - 10.1016/0014-5793(90)80276-O

M3 - Article

C2 - 2114322

AN - SCOPUS:0025369479

VL - 267

SP - 16

EP - 18

JO - FEBS Letters

JF - FEBS Letters

SN - 0014-5793

IS - 1

ER -