Abstract
We have investigated the effect of glucose on the release of endothelin-1-like immunoreactivity (ET-l-LI) from cultured bovine aortic endothelial cells. Elevation of glucose concentrations in cultured media from 5.5 to 11.1 or 22.2 mM significantly stimulated ET-1-LI release from cultured endothelial cells. An aldose reductase inhibitor did not affect the high glucose-induced ET-1-LI release, These findings suggest the possibility that hyperglycemia in diabetic patients enhances ET-1-LI release at the local site of vascular endothelium. which might be involved in the developments of vascular complications and atherosclerosis.
Original language | English |
---|---|
Pages (from-to) | 16-18 |
Number of pages | 3 |
Journal | FEBS Letters |
Volume | 267 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jul 2 1990 |
All Science Journal Classification (ASJC) codes
- Biophysics
- Structural Biology
- Biochemistry
- Molecular Biology
- Genetics
- Cell Biology