Enhanced stability of siRNA complex with bottle brush-type cationic copolymers - Effect of brush density

Takeshi Yamano, Sung Won Choi, Asako Yamayoshi, Arihiro Kano, Atsushi Maruyama

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Small interfering RNA (siRNA) holds potential as a therapeutic approach to silence targeted gene of disease, but siRNA has limited stability in vivo. Therefore, delivery system of siRNA is the key to siRNA therapeutic application. We have examined bottle brush-type copolymers (BBC) as a long circulation siRNA carrier. In this study, effects of polyethylene glycol)(PEG) brush of BBCs on interaction between siRNA and copolymers were evaluated. As a result, we observed that BBC having higher PEG density shows stronger interaction with siRNA.

Original languageEnglish
Title of host publication55th SPSJ Symposium on Macromolecules
Pages5375-5376
Number of pages2
Volume55
Edition2
Publication statusPublished - 2006
Externally publishedYes
Event55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan
Duration: Sep 20 2006Sep 22 2006

Other

Other55th Society of Polymer Science Japan Symposium on Macromolecules
CountryJapan
CityToyama
Period9/20/069/22/06

All Science Journal Classification (ASJC) codes

  • Engineering(all)

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    Yamano, T., Choi, S. W., Yamayoshi, A., Kano, A., & Maruyama, A. (2006). Enhanced stability of siRNA complex with bottle brush-type cationic copolymers - Effect of brush density. In 55th SPSJ Symposium on Macromolecules (2 ed., Vol. 55, pp. 5375-5376)