Enhanced stability of siRNA complex with bottle brush-type cationic copolymers - Effect of brush density

Takeshi Yamano; Sung Won Choi; Asako Yamayoshi; Arihiro Kano; Atsushi Maruyama

Enhanced stability of siRNA complex with bottle brush-type cationic copolymers - Effect of brush density

Takeshi Yamano, Sung Won Choi, Asako Yamayoshi, Arihiro Kano, Atsushi Maruyama

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Small interfering RNA (siRNA) holds potential as a therapeutic approach to silence targeted gene of disease, but siRNA has limited stability in vivo. Therefore, delivery system of siRNA is the key to siRNA therapeutic application. We have examined bottle brush-type copolymers (BBC) as a long circulation siRNA carrier. In this study, effects of polyethylene glycol)(PEG) brush of BBCs on interaction between siRNA and copolymers were evaluated. As a result, we observed that BBC having higher PEG density shows stronger interaction with siRNA.

Original language	English
Title of host publication	55th SPSJ Symposium on Macromolecules
Pages	5375-5376
Number of pages	2
Volume	55
Edition	2
Publication status	Published - 2006
Externally published	Yes
Event	55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan Duration: Sept 20 2006 → Sept 22 2006

Other

Other	55th Society of Polymer Science Japan Symposium on Macromolecules
Country/Territory	Japan
City	Toyama
Period	9/20/06 → 9/22/06

All Science Journal Classification (ASJC) codes

Engineering(all)

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@inproceedings{0874840d5cdb476c8316749a571ce3eb,

title = "Enhanced stability of siRNA complex with bottle brush-type cationic copolymers - Effect of brush density",

abstract = "Small interfering RNA (siRNA) holds potential as a therapeutic approach to silence targeted gene of disease, but siRNA has limited stability in vivo. Therefore, delivery system of siRNA is the key to siRNA therapeutic application. We have examined bottle brush-type copolymers (BBC) as a long circulation siRNA carrier. In this study, effects of polyethylene glycol)(PEG) brush of BBCs on interaction between siRNA and copolymers were evaluated. As a result, we observed that BBC having higher PEG density shows stronger interaction with siRNA.",

author = "Takeshi Yamano and Choi, {Sung Won} and Asako Yamayoshi and Arihiro Kano and Atsushi Maruyama",

year = "2006",

language = "English",

volume = "55",

pages = "5375--5376",

booktitle = "55th SPSJ Symposium on Macromolecules",

edition = "2",

note = "55th Society of Polymer Science Japan Symposium on Macromolecules ; Conference date: 20-09-2006 Through 22-09-2006",

}

TY - GEN

T1 - Enhanced stability of siRNA complex with bottle brush-type cationic copolymers - Effect of brush density

AU - Yamano, Takeshi

AU - Choi, Sung Won

AU - Yamayoshi, Asako

AU - Kano, Arihiro

AU - Maruyama, Atsushi

PY - 2006

Y1 - 2006

N2 - Small interfering RNA (siRNA) holds potential as a therapeutic approach to silence targeted gene of disease, but siRNA has limited stability in vivo. Therefore, delivery system of siRNA is the key to siRNA therapeutic application. We have examined bottle brush-type copolymers (BBC) as a long circulation siRNA carrier. In this study, effects of polyethylene glycol)(PEG) brush of BBCs on interaction between siRNA and copolymers were evaluated. As a result, we observed that BBC having higher PEG density shows stronger interaction with siRNA.

AB - Small interfering RNA (siRNA) holds potential as a therapeutic approach to silence targeted gene of disease, but siRNA has limited stability in vivo. Therefore, delivery system of siRNA is the key to siRNA therapeutic application. We have examined bottle brush-type copolymers (BBC) as a long circulation siRNA carrier. In this study, effects of polyethylene glycol)(PEG) brush of BBCs on interaction between siRNA and copolymers were evaluated. As a result, we observed that BBC having higher PEG density shows stronger interaction with siRNA.

UR - http://www.scopus.com/inward/record.url?scp=33846128157&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846128157&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:33846128157

VL - 55

SP - 5375

EP - 5376

BT - 55th SPSJ Symposium on Macromolecules

T2 - 55th Society of Polymer Science Japan Symposium on Macromolecules

Y2 - 20 September 2006 through 22 September 2006

ER -

Enhanced stability of siRNA complex with bottle brush-type cationic copolymers - Effect of brush density

Abstract

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All Science Journal Classification (ASJC) codes

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