Enhancement of cell function through heterotypic cell-cell interactions using E-cadherin-expressing NIH3T3 cells

Akira Ito, Takehiko Kiyohara, Yoshinori Kawabe, Hiroyuki Ijima, Masamichi Kamihira

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11 Citations (Scopus)


An epithelial cell adhesion molecule, E-cadherin was expressed in NIH3T3 fibroblasts, and cell-cell interactions between keratinocytes and fibroblasts, or between hepatocytes and fibroblasts were artificially engineered. When the E-cadherin-expressing NIH3T3 cells were co-cultured with rat hepatocytes, the cell-cell contacts were formed with high frequency, and enhanced albumin secretion was observed.

Original languageEnglish
Pages (from-to)679-682
Number of pages4
JournalJournal of Bioscience and Bioengineering
Issue number6
Publication statusPublished - Jun 1 2008


All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

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