Enhancement of cell function through heterotypic cell-cell interactions using E-cadherin-expressing NIH3T3 cells

Akira Ito; Takehiko Kiyohara; Yoshinori Kawabe; Hiroyuki Ijima; Masamichi Kamihira

doi:10.1263/jbb.105.679

Enhancement of cell function through heterotypic cell-cell interactions using E-cadherin-expressing NIH3T3 cells

Akira Ito, Takehiko Kiyohara, Yoshinori Kawabe, Hiroyuki Ijima, Masamichi Kamihira

Molecular and Biochemical Systems Engineering

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

An epithelial cell adhesion molecule, E-cadherin was expressed in NIH3T3 fibroblasts, and cell-cell interactions between keratinocytes and fibroblasts, or between hepatocytes and fibroblasts were artificially engineered. When the E-cadherin-expressing NIH3T3 cells were co-cultured with rat hepatocytes, the cell-cell contacts were formed with high frequency, and enhanced albumin secretion was observed.

Original language	English
Pages (from-to)	679-682
Number of pages	4
Journal	Journal of Bioscience and Bioengineering
Volume	105
Issue number	6
DOIs	https://doi.org/10.1263/jbb.105.679
Publication status	Published - Jun 2008

All Science Journal Classification (ASJC) codes

Biotechnology
Bioengineering
Applied Microbiology and Biotechnology

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abstract = "An epithelial cell adhesion molecule, E-cadherin was expressed in NIH3T3 fibroblasts, and cell-cell interactions between keratinocytes and fibroblasts, or between hepatocytes and fibroblasts were artificially engineered. When the E-cadherin-expressing NIH3T3 cells were co-cultured with rat hepatocytes, the cell-cell contacts were formed with high frequency, and enhanced albumin secretion was observed.",

author = "Akira Ito and Takehiko Kiyohara and Yoshinori Kawabe and Hiroyuki Ijima and Masamichi Kamihira",

note = "Funding Information: This work was supported in part by Grants-in-Aid for Scientific Research (nos. 18048024 and 19686049) from the Japan Society for the Promotion of Science (JSPS).",

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AU - Ito, Akira

AU - Kiyohara, Takehiko

AU - Kawabe, Yoshinori

AU - Ijima, Hiroyuki

AU - Kamihira, Masamichi

N1 - Funding Information: This work was supported in part by Grants-in-Aid for Scientific Research (nos. 18048024 and 19686049) from the Japan Society for the Promotion of Science (JSPS).

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N2 - An epithelial cell adhesion molecule, E-cadherin was expressed in NIH3T3 fibroblasts, and cell-cell interactions between keratinocytes and fibroblasts, or between hepatocytes and fibroblasts were artificially engineered. When the E-cadherin-expressing NIH3T3 cells were co-cultured with rat hepatocytes, the cell-cell contacts were formed with high frequency, and enhanced albumin secretion was observed.

AB - An epithelial cell adhesion molecule, E-cadherin was expressed in NIH3T3 fibroblasts, and cell-cell interactions between keratinocytes and fibroblasts, or between hepatocytes and fibroblasts were artificially engineered. When the E-cadherin-expressing NIH3T3 cells were co-cultured with rat hepatocytes, the cell-cell contacts were formed with high frequency, and enhanced albumin secretion was observed.

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Enhancement of cell function through heterotypic cell-cell interactions using E-cadherin-expressing NIH3T3 cells

Abstract

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