Enhancement of cellular glucose uptake by reactive species: A promising approach for diabetes therapy

Naresh Kumar, Priyanka Shaw, Jamoliddin Razzokov, Maksudbek Yusupov, Pankaj Attri, Han Sup Uhm, Eun Ha Choi, Annemie Bogaerts

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

It is generally known that antidiabetic activity is associated with an increased level of glucose uptake in adipocytes and skeletal muscle cells. However, the role of exogenous reactive oxygen and nitrogen species (RONS) in muscle development and more importantly in glucose uptake is largely unknown. We investigate the effect of RONS generated by cold atmospheric plasma (CAP) in glucose uptake. We show that the glucose uptake is significantly enhanced in differentiated L6 skeletal muscle cells after CAP treatment. We also observe a significant increase of the intracellular Ca++ and ROS level, without causing toxicity. One of the possible reasons for an elevated level of glucose uptake as well as intracellular ROS and Ca++ ions is probably the increased oxidative stress leading to glucose transport.

Original languageEnglish
Pages (from-to)9887-9894
Number of pages8
JournalRSC Advances
Volume8
Issue number18
DOIs
Publication statusPublished - 2018
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

Fingerprint Dive into the research topics of 'Enhancement of cellular glucose uptake by reactive species: A promising approach for diabetes therapy'. Together they form a unique fingerprint.

Cite this