Enhancement of saccharothriolide production and discovery of a new metabolite, saccharothriolide C 2 , by combined-culture of Saccharothrix sp. and Tsukamurella pulmonis

Yulu Jiang, Shan Lu, Go Hirai, Taira Kato, Hiroyasu Onaka, Hideaki Kakeya

Research output: Contribution to journalArticle

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Abstract

A combined-culture method was applied to saccharothriolide-producing strain Saccharothrix sp. A1506 with the mycolic acid-containing bacterium (MACB) Tsukamurella pulmonis TP-B0596. The combined-culture not only enhanced saccharothriolide production, but also produced saccharothriolide C 2 , a new C-2 epimer of saccharothriolide C, thereby indicating its potential for increasing the chemical diversity of microbial metabolites.

Original languageEnglish
Pages (from-to)1072-1074
Number of pages3
JournalTetrahedron Letters
Volume60
Issue number15
DOIs
Publication statusPublished - Apr 11 2019

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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