Abstract
New ent-trachylobane-3β-hydroperoxide (5) together with four known compounds, ricinine (1), trimethoxy ellagic acid (2), dimethoxy ellagic acid (3) and aleurotolic acid (4) were isolated from the methylene chloride fraction of the root bark of Chrozophora oblongifolia. The structures of these secondary metabolites were elucidated by using different spectroscopic techniques, 1H NMR, 13C NMR, HSQC, HMBC, 1H-1H COSY, NOESY, HR-ESI-MS, EI-MS and comparison with published data. Ent-trachylobane-3β-hydroperoxide showed moderate cytotoxic activity by MTT assay method against human breast cancer cells (MCF-7) and human hepatocyte-derived carcinoma cells (Huh-7) with IC50 values of 24.53 and 34.13 µM, in comparison with IC50 values of 23.47 µM and 15.82 µM for 5-fluorouracil respectively.
| Original language | English |
|---|---|
| Journal | Natural Product Research |
| DOIs | |
| Publication status | Accepted/In press - Jan 1 2019 |
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All Science Journal Classification (ASJC) codes
- Analytical Chemistry
- Biochemistry
- Plant Science
- Organic Chemistry
Cite this
Ent-trachylobane-3β-hydroperoxide, a new diterpene from the root bark of Chrozophora oblongifolia (Fam.; Euphorbiaceae). / Kamel, Mohamed R.; Nafady, Alaa M.; Hassanein, Ahmed M.M.; Hassan, Ahmed R.; Shimizu, Kuniyoshi; Ibrahim, Reham R.; Haggag, Eman G.
In: Natural Product Research, 01.01.2019.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Ent-trachylobane-3β-hydroperoxide, a new diterpene from the root bark of Chrozophora oblongifolia (Fam.; Euphorbiaceae)
AU - Kamel, Mohamed R.
AU - Nafady, Alaa M.
AU - Hassanein, Ahmed M.M.
AU - Hassan, Ahmed R.
AU - Shimizu, Kuniyoshi
AU - Ibrahim, Reham R.
AU - Haggag, Eman G.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - New ent-trachylobane-3β-hydroperoxide (5) together with four known compounds, ricinine (1), trimethoxy ellagic acid (2), dimethoxy ellagic acid (3) and aleurotolic acid (4) were isolated from the methylene chloride fraction of the root bark of Chrozophora oblongifolia. The structures of these secondary metabolites were elucidated by using different spectroscopic techniques, 1H NMR, 13C NMR, HSQC, HMBC, 1H-1H COSY, NOESY, HR-ESI-MS, EI-MS and comparison with published data. Ent-trachylobane-3β-hydroperoxide showed moderate cytotoxic activity by MTT assay method against human breast cancer cells (MCF-7) and human hepatocyte-derived carcinoma cells (Huh-7) with IC50 values of 24.53 and 34.13 µM, in comparison with IC50 values of 23.47 µM and 15.82 µM for 5-fluorouracil respectively.
AB - New ent-trachylobane-3β-hydroperoxide (5) together with four known compounds, ricinine (1), trimethoxy ellagic acid (2), dimethoxy ellagic acid (3) and aleurotolic acid (4) were isolated from the methylene chloride fraction of the root bark of Chrozophora oblongifolia. The structures of these secondary metabolites were elucidated by using different spectroscopic techniques, 1H NMR, 13C NMR, HSQC, HMBC, 1H-1H COSY, NOESY, HR-ESI-MS, EI-MS and comparison with published data. Ent-trachylobane-3β-hydroperoxide showed moderate cytotoxic activity by MTT assay method against human breast cancer cells (MCF-7) and human hepatocyte-derived carcinoma cells (Huh-7) with IC50 values of 24.53 and 34.13 µM, in comparison with IC50 values of 23.47 µM and 15.82 µM for 5-fluorouracil respectively.
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UR - http://www.scopus.com/inward/citedby.url?scp=85074849041&partnerID=8YFLogxK
U2 - 10.1080/14786419.2019.1687477
DO - 10.1080/14786419.2019.1687477
M3 - Article
C2 - 31691590
AN - SCOPUS:85074849041
JO - Natural Product Research
JF - Natural Product Research
SN - 1478-6419
ER -