Enteric nervous system and endocrine cells demonstrated in the gut in teratomas

Ryuichiro Hirose, Tomoaki Taguchi, Sachiyo Suita, Osami Nada

Research output: Contribution to journalArticle

Abstract

A case of retroperitoneal teratoma, showing considerable morphological development presented as an encapsulated and pedunculated tumour with a seemingly mature intestinal loop. Markedly complex intramural nerve plexuses and numerous epithelial endocrine cells were revealed immunohistochemically in the gut tissue. Ten other mature teratomas containing gastrointestinal tissues were examined for comparison, but neither intramural ganglia nor nervous networks were found in the gut components, despite the presence of amine- and/or peptide-containing endocrine cells in all intestinal mucosa linings. Enteric endocrine cells were found to occur irrespective of the differentiation of intestinal layers or the occurrence of neural elements. These findings suggest that the epithelial endocrine cells of intestinal mucosa do not have the same origin as enteric neurons, but are rather of endodermal origin. This invertebrate well-formed teratoma, containing a highly organized enteric nervous system, suggests that teratoma and fetus in fetu are related entities distinguished by the presence of a vertebral axis.

Original languageEnglish
Pages (from-to)499-506
Number of pages8
JournalVirchows Archiv A Pathological Anatomy and Histopathology
Volume422
Issue number6
DOIs
Publication statusPublished - Nov 1 1993

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Enteric Nervous System
Endocrine Cells
Teratoma
Intestinal Mucosa
Epithelial Cells
Invertebrates
Ganglia
Amines
Fetus
Neurons
Peptides
Neoplasms

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Enteric nervous system and endocrine cells demonstrated in the gut in teratomas. / Hirose, Ryuichiro; Taguchi, Tomoaki; Suita, Sachiyo; Nada, Osami.

In: Virchows Archiv A Pathological Anatomy and Histopathology, Vol. 422, No. 6, 01.11.1993, p. 499-506.

Research output: Contribution to journalArticle

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