Entrainment function in the suprachiasmatic nucleus of streptozotocin-induced diabetic rats

T. Shimazoe; J. Ishida; M. Maetani; T. Yakabe; M. Yamaguchi; K. Miyasaka; A. Kono; S. Watanabe; A. Funakoshi

doi:10.1254/jjp.83.355

Entrainment function in the suprachiasmatic nucleus of streptozotocin-induced diabetic rats

T. Shimazoe, J. Ishida, M. Maetani, T. Yakabe, M. Yamaguchi, K. Miyasaka, A. Kono, S. Watanabe, A. Funakoshi

Pharmaceutical Health Care and Sciences Faculty

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

The term for re-entrainment to a new light-dark cycle in streptozotocin (STZ)-induced diabetic rats was significantly longer than that in control rats. In STZ-induced diabetic rats, the same level of phase delay in the suprachiasmatic nucleus neuronal firing rhythm was observed in control rats after glutamate application. Therefore, 5-HT function in the hypothalamus is thought to be decreased in STZ-induced diabetic rats. These results suggest that postsynaptic neuronal function is still maintained in the suprachiasmatic nucleus of STZ-induced diabetic rats. Therefore, 5-HT mechanisms may play an important role in the maintenance of this function.

Original language	English
Pages (from-to)	355-358
Number of pages	4
Journal	Japanese Journal of Pharmacology
Volume	83
Issue number	4
DOIs	https://doi.org/10.1254/jjp.83.355
Publication status	Published - 2000

All Science Journal Classification (ASJC) codes

Pharmacology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1254/jjp.83.355

Cite this

@article{ece8851f7bc74d9a8c21506da68c2bb1,

title = "Entrainment function in the suprachiasmatic nucleus of streptozotocin-induced diabetic rats",

abstract = "The term for re-entrainment to a new light-dark cycle in streptozotocin (STZ)-induced diabetic rats was significantly longer than that in control rats. In STZ-induced diabetic rats, the same level of phase delay in the suprachiasmatic nucleus neuronal firing rhythm was observed in control rats after glutamate application. Therefore, 5-HT function in the hypothalamus is thought to be decreased in STZ-induced diabetic rats. These results suggest that postsynaptic neuronal function is still maintained in the suprachiasmatic nucleus of STZ-induced diabetic rats. Therefore, 5-HT mechanisms may play an important role in the maintenance of this function.",

author = "T. Shimazoe and J. Ishida and M. Maetani and T. Yakabe and M. Yamaguchi and K. Miyasaka and A. Kono and S. Watanabe and A. Funakoshi",

year = "2000",

doi = "10.1254/jjp.83.355",

language = "English",

volume = "83",

pages = "355--358",

journal = "Japanese Journal of Pharmacology",

issn = "0021-5198",

publisher = "Japanese Pharmacological Society",

number = "4",

}

TY - JOUR

T1 - Entrainment function in the suprachiasmatic nucleus of streptozotocin-induced diabetic rats

AU - Shimazoe, T.

AU - Ishida, J.

AU - Maetani, M.

AU - Yakabe, T.

AU - Yamaguchi, M.

AU - Miyasaka, K.

AU - Kono, A.

AU - Watanabe, S.

AU - Funakoshi, A.

PY - 2000

Y1 - 2000

N2 - The term for re-entrainment to a new light-dark cycle in streptozotocin (STZ)-induced diabetic rats was significantly longer than that in control rats. In STZ-induced diabetic rats, the same level of phase delay in the suprachiasmatic nucleus neuronal firing rhythm was observed in control rats after glutamate application. Therefore, 5-HT function in the hypothalamus is thought to be decreased in STZ-induced diabetic rats. These results suggest that postsynaptic neuronal function is still maintained in the suprachiasmatic nucleus of STZ-induced diabetic rats. Therefore, 5-HT mechanisms may play an important role in the maintenance of this function.

AB - The term for re-entrainment to a new light-dark cycle in streptozotocin (STZ)-induced diabetic rats was significantly longer than that in control rats. In STZ-induced diabetic rats, the same level of phase delay in the suprachiasmatic nucleus neuronal firing rhythm was observed in control rats after glutamate application. Therefore, 5-HT function in the hypothalamus is thought to be decreased in STZ-induced diabetic rats. These results suggest that postsynaptic neuronal function is still maintained in the suprachiasmatic nucleus of STZ-induced diabetic rats. Therefore, 5-HT mechanisms may play an important role in the maintenance of this function.

UR - http://www.scopus.com/inward/record.url?scp=0033822096&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033822096&partnerID=8YFLogxK

U2 - 10.1254/jjp.83.355

DO - 10.1254/jjp.83.355

M3 - Article

C2 - 11001184

AN - SCOPUS:0033822096

SN - 0021-5198

VL - 83

SP - 355

EP - 358

JO - Japanese Journal of Pharmacology

JF - Japanese Journal of Pharmacology

IS - 4

ER -

Entrainment function in the suprachiasmatic nucleus of streptozotocin-induced diabetic rats

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this