TY - JOUR
T1 - Environmental factors for establishment of the dormant state in oocytes
AU - Hayashi, Katsuhiko
AU - Shimamoto, So
AU - Nagamatsu, Go
N1 - Funding Information:
This study was supported in part by KAKENHI Grants-in-Aid from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (nos. 25290033, 25114006, 17H01395, 18H05544 and 18H05545 to K.H. and no. 18K06261 to G.N.); by Management Expenses Grants of Kyushu University (K.H.); by the Uehara Memorial Foundation (K.H.); by the Takeda Science Foundation (K.H.); by a Hayashi Grant-in-Aid for Basic Medical Research, Kyushu University (K.H.); and by a Grant-in-Aid from The Open Philanthropy Project (K.H.)
Publisher Copyright:
© 2020 Kyushu University, Japan. Development, Growth & Differentiation published by John Wiley & Sons Australia, Ltd. on behalf of Japanese Society of Developmental Biologists
PY - 2020/4/1
Y1 - 2020/4/1
N2 - Guaranteeing the sustainability of gametogenesis is a fundamental issue for perpetuating the species. In the mammalian ovary, sustainability is accomplished by keeping a number of oocytes “stocked” in the dormant state. Despite the evident importance of this state, the mechanisms underlying the oocyte dormancy are not fully understood, although it is presumed that both intrinsic and extrinsic factors are involved. Here, we review environmental factors involved in the regulation of oocyte dormancy. Consideration of the environmental factors illustrates the nature of the ovarian compartment, in which primordial follicles reside. This should greatly improve our understanding of the mechanisms and also assist in reconstitution of the dormant state in culture. Accumulating knowledge on the dormant state of oocytes will contribute to a wide range of research in fields such as developmental biology, reproductive biology and regenerative medicine.
AB - Guaranteeing the sustainability of gametogenesis is a fundamental issue for perpetuating the species. In the mammalian ovary, sustainability is accomplished by keeping a number of oocytes “stocked” in the dormant state. Despite the evident importance of this state, the mechanisms underlying the oocyte dormancy are not fully understood, although it is presumed that both intrinsic and extrinsic factors are involved. Here, we review environmental factors involved in the regulation of oocyte dormancy. Consideration of the environmental factors illustrates the nature of the ovarian compartment, in which primordial follicles reside. This should greatly improve our understanding of the mechanisms and also assist in reconstitution of the dormant state in culture. Accumulating knowledge on the dormant state of oocytes will contribute to a wide range of research in fields such as developmental biology, reproductive biology and regenerative medicine.
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U2 - 10.1111/dgd.12653
DO - 10.1111/dgd.12653
M3 - Review article
C2 - 32106340
AN - SCOPUS:85080108406
VL - 62
SP - 150
EP - 157
JO - Development Growth and Differentiation
JF - Development Growth and Differentiation
SN - 0012-1592
IS - 3
ER -