Abstract
Surfactant-coated lipases have been utilized as a biocatalyst for the resolution of racemic ibuprofen. S-(+)-ibuprofen was selectively transferred to the ester form by Mucor javanicus or Candida rugosa lipase. The enzymatic activity of lipases in organic media was remarkably enhanced by coating with a nonionic surfactant. The reaction rates of the coated lipases were increased around 100-fold that of the powder lipases.
| Original language | English |
|---|---|
| Pages (from-to) | 839-844 |
| Number of pages | 6 |
| Journal | Biotechnology letters |
| Volume | 18 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Jul 29 1996 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Biotechnology
- Bioengineering
- Applied Microbiology and Biotechnology
Cite this
Enzymatic resolution of racemic ibuprofen by surfactant-coated lipases in organic media. / Goto, Masahiro; Noda, Sadafumi; Kamiya, Noriho; Nakashio, Fumiyuki.
In: Biotechnology letters, Vol. 18, No. 7, 29.07.1996, p. 839-844.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Enzymatic resolution of racemic ibuprofen by surfactant-coated lipases in organic media
AU - Goto, Masahiro
AU - Noda, Sadafumi
AU - Kamiya, Noriho
AU - Nakashio, Fumiyuki
PY - 1996/7/29
Y1 - 1996/7/29
N2 - Surfactant-coated lipases have been utilized as a biocatalyst for the resolution of racemic ibuprofen. S-(+)-ibuprofen was selectively transferred to the ester form by Mucor javanicus or Candida rugosa lipase. The enzymatic activity of lipases in organic media was remarkably enhanced by coating with a nonionic surfactant. The reaction rates of the coated lipases were increased around 100-fold that of the powder lipases.
AB - Surfactant-coated lipases have been utilized as a biocatalyst for the resolution of racemic ibuprofen. S-(+)-ibuprofen was selectively transferred to the ester form by Mucor javanicus or Candida rugosa lipase. The enzymatic activity of lipases in organic media was remarkably enhanced by coating with a nonionic surfactant. The reaction rates of the coated lipases were increased around 100-fold that of the powder lipases.
UR - http://www.scopus.com/inward/record.url?scp=0030018839&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030018839&partnerID=8YFLogxK
U2 - 10.1007/BF00127899
DO - 10.1007/BF00127899
M3 - Article
AN - SCOPUS:0030018839
VL - 18
SP - 839
EP - 844
JO - Biotechnology Letters
JF - Biotechnology Letters
SN - 0141-5492
IS - 7
ER -