Enzymatic resolution of racemic ibuprofen by surfactant-coated lipases in organic media

Masahiro Goto, Sadafumi Noda, Noriho Kamiya, Fumiyuki Nakashio

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

Surfactant-coated lipases have been utilized as a biocatalyst for the resolution of racemic ibuprofen. S-(+)-ibuprofen was selectively transferred to the ester form by Mucor javanicus or Candida rugosa lipase. The enzymatic activity of lipases in organic media was remarkably enhanced by coating with a nonionic surfactant. The reaction rates of the coated lipases were increased around 100-fold that of the powder lipases.

Original languageEnglish
Pages (from-to)839-844
Number of pages6
JournalBiotechnology letters
Volume18
Issue number7
DOIs
Publication statusPublished - Jul 29 1996

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

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