Enzymatic resolution of racemic ibuprofen by surfactant-coated lipases in organic media

Masahiro Goto; Sadafumi Noda; Noriho Kamiya; Fumiyuki Nakashio

doi:10.1007/BF00127899

Enzymatic resolution of racemic ibuprofen by surfactant-coated lipases in organic media

Masahiro Goto, Sadafumi Noda, Noriho Kamiya, Fumiyuki Nakashio

Chemistry and Biochemistry

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

Surfactant-coated lipases have been utilized as a biocatalyst for the resolution of racemic ibuprofen. S-(+)-ibuprofen was selectively transferred to the ester form by Mucor javanicus or Candida rugosa lipase. The enzymatic activity of lipases in organic media was remarkably enhanced by coating with a nonionic surfactant. The reaction rates of the coated lipases were increased around 100-fold that of the powder lipases.

Original language	English
Pages (from-to)	839-844
Number of pages	6
Journal	Biotechnology letters
Volume	18
Issue number	7
DOIs	https://doi.org/10.1007/BF00127899
Publication status	Published - 1996

All Science Journal Classification (ASJC) codes

Biotechnology
Bioengineering
Applied Microbiology and Biotechnology

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10.1007/BF00127899

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abstract = "Surfactant-coated lipases have been utilized as a biocatalyst for the resolution of racemic ibuprofen. S-(+)-ibuprofen was selectively transferred to the ester form by Mucor javanicus or Candida rugosa lipase. The enzymatic activity of lipases in organic media was remarkably enhanced by coating with a nonionic surfactant. The reaction rates of the coated lipases were increased around 100-fold that of the powder lipases.",

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AU - Noda, Sadafumi

AU - Kamiya, Noriho

AU - Nakashio, Fumiyuki

PY - 1996

Y1 - 1996

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AB - Surfactant-coated lipases have been utilized as a biocatalyst for the resolution of racemic ibuprofen. S-(+)-ibuprofen was selectively transferred to the ester form by Mucor javanicus or Candida rugosa lipase. The enzymatic activity of lipases in organic media was remarkably enhanced by coating with a nonionic surfactant. The reaction rates of the coated lipases were increased around 100-fold that of the powder lipases.

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Enzymatic resolution of racemic ibuprofen by surfactant-coated lipases in organic media

Abstract

All Science Journal Classification (ASJC) codes

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