Enzymatic synthesis of sugar amino acid esters in organic solvents

Tatsuo Maruyama, Shin Ichiro Nagasawa, Masahiro Goto

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)


The enzymatic synthesis of sugar amino acid esters in polar organic solvents was studied using surfactant-enzyme complexes, which were previously developed as a highly active biocatalyst in organic solvents. Of the several lipases and proteases tested, the surfactant-subtilisin complex exhibited the highest synthetic activity in pyridine. The amino acid was regioselectively introduced at the C-6 position of D-glucose and at the C-6' of maltose by the surfactant-subtilisin complex. This biocatalyst was found to effectively catalyze the synthesis of various sugar amino acid esters in a polar organic solvent.

Original languageEnglish
Pages (from-to)357-361
Number of pages5
JournalJournal of Bioscience and Bioengineering
Issue number4
Publication statusPublished - Jan 1 2002

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

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