Enzymes of the one-carbon folate metabolism as anticancer targets predicted by survival rate analysis

Jun Koseki, Masamitsu Konno, Ayumu Asai, Hugh Colvin, Koichi Kawamoto, Naohiro Nishida, Daisuke Sakai, Toshihiro Kudo, Taroh Satoh, Yuichiro Doki, Masaki Mori, Hideshi Ishii

Research output: Contribution to journalArticle

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Abstract

The significance of mitochondrial metabolism in cancer cells has recently been gaining attention. Among other findings, One-carbon folate metabolism has been reported to be closely associated with cellular characteristics in cancer. To study molecular targets for efficient cancer therapy, we investigated the association between the expressions of genes that code enzymes involved in one-carbon metabolism and survival rate of patients with adenocarcinomas of the colorectum and lung. Patients with high expression of genes that control the metabolic cycle of tetrahydrofolate (THF) in mitochondria, SHMT2, MTHFD2, and ALDH1L2, have a shorter overall survival rate compared with patients with low expression of these genes. Our results revealed that these genes could be novel and more promising anticancer targets than dihydrofolate reductase (DHFR), the current target of drug therapy linked with folate metabolism, suggesting the rationale of drug discovery in cancer medicine.

Original languageEnglish
Article number303
JournalScientific reports
Volume8
Issue number1
DOIs
Publication statusPublished - Dec 1 2018
Externally publishedYes

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Survival Analysis
Folic Acid
Carbon
Survival Rate
Enzymes
Gene Expression
Neoplasms
Tetrahydrofolate Dehydrogenase
Drug Discovery
Mitochondria
Medicine
Drug Therapy
Genes
Therapeutics

All Science Journal Classification (ASJC) codes

  • General

Cite this

Koseki, J., Konno, M., Asai, A., Colvin, H., Kawamoto, K., Nishida, N., ... Ishii, H. (2018). Enzymes of the one-carbon folate metabolism as anticancer targets predicted by survival rate analysis. Scientific reports, 8(1), [303]. https://doi.org/10.1038/s41598-017-18456-x

Enzymes of the one-carbon folate metabolism as anticancer targets predicted by survival rate analysis. / Koseki, Jun; Konno, Masamitsu; Asai, Ayumu; Colvin, Hugh; Kawamoto, Koichi; Nishida, Naohiro; Sakai, Daisuke; Kudo, Toshihiro; Satoh, Taroh; Doki, Yuichiro; Mori, Masaki; Ishii, Hideshi.

In: Scientific reports, Vol. 8, No. 1, 303, 01.12.2018.

Research output: Contribution to journalArticle

Koseki, J, Konno, M, Asai, A, Colvin, H, Kawamoto, K, Nishida, N, Sakai, D, Kudo, T, Satoh, T, Doki, Y, Mori, M & Ishii, H 2018, 'Enzymes of the one-carbon folate metabolism as anticancer targets predicted by survival rate analysis', Scientific reports, vol. 8, no. 1, 303. https://doi.org/10.1038/s41598-017-18456-x
Koseki, Jun ; Konno, Masamitsu ; Asai, Ayumu ; Colvin, Hugh ; Kawamoto, Koichi ; Nishida, Naohiro ; Sakai, Daisuke ; Kudo, Toshihiro ; Satoh, Taroh ; Doki, Yuichiro ; Mori, Masaki ; Ishii, Hideshi. / Enzymes of the one-carbon folate metabolism as anticancer targets predicted by survival rate analysis. In: Scientific reports. 2018 ; Vol. 8, No. 1.
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