Eosinophilic airway inflammation induced by repeated exposure to cigarette smoke

Koichiro Matsumoto, H. Aizawa, H. Inoue, H. Koto, S. Takata, M. Shigyo, H. Nakano, N. Hara

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Acute exposure to cigarette smoke causes airway hyperresponsiveness (AHR) in guinea-pigs, which resolves within a few hours. Repeated exposure may have a different effect on the airways. To address this question, guinea- pigs were repeatedly exposed to cigarette smoke (six cigarettes for 1 h·day -1 ) for 14 consecutive days. Airway responsiveness to inhaled histamine and differential cell counts in bronchoalveolar lavage fluid (BALF) were evaluated 1 day after the last exposure. Significant neutrophilia in BALF was observed after 3 days of smoke exposure. Significant eosinophilia in BALF and AHR were observed after 14 days of smoke exposure, but not after 3 or 7 days of smoke exposure. These changes persisted until 3 days after the last exposure and resolved 7 days afterwards. Histologically, the recruited eosinophils were observed predominantly in the airways, but not in the alveoli. Treatment with E-6123, a specific platelet-activating factor receptor antagonist (1 mg·kg -1 ·day -1 p.o. during smoke exposure) significantly inhibited the eosinophil influx and AHR. Repeated exposure to cigarette smoke may induce prolonged airway inflammation and airway hyperresponsiveness in guinea-pigs. Platelet-activating factor or platelet- activating factor-like lipids may play a key role in airway hyperresponsiveness, presumably by the induction of eosinophilic airway inflammation.

Original languageEnglish
Pages (from-to)387-394
Number of pages8
JournalEuropean Respiratory Journal
Volume12
Issue number2
DOIs
Publication statusPublished - Jan 1 1998

Fingerprint

Smoke
Tobacco Products
Inflammation
Bronchoalveolar Lavage Fluid
Guinea Pigs
E 6123
Platelet Activating Factor
Eosinophils
Eosinophilia
Histamine
Cell Count
Lipids

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine

Cite this

Eosinophilic airway inflammation induced by repeated exposure to cigarette smoke. / Matsumoto, Koichiro; Aizawa, H.; Inoue, H.; Koto, H.; Takata, S.; Shigyo, M.; Nakano, H.; Hara, N.

In: European Respiratory Journal, Vol. 12, No. 2, 01.01.1998, p. 387-394.

Research output: Contribution to journalArticle

Matsumoto, K, Aizawa, H, Inoue, H, Koto, H, Takata, S, Shigyo, M, Nakano, H & Hara, N 1998, 'Eosinophilic airway inflammation induced by repeated exposure to cigarette smoke', European Respiratory Journal, vol. 12, no. 2, pp. 387-394. https://doi.org/10.1183/09031936.98.12020387
Matsumoto, Koichiro ; Aizawa, H. ; Inoue, H. ; Koto, H. ; Takata, S. ; Shigyo, M. ; Nakano, H. ; Hara, N. / Eosinophilic airway inflammation induced by repeated exposure to cigarette smoke. In: European Respiratory Journal. 1998 ; Vol. 12, No. 2. pp. 387-394.
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