Ependyma-lined canal with surrounding neuroglial tissues in lumbosacral lipomatous malformations: Relationship with retained medullary cord

Nobuya Murakami, Takato Morioka, Takafumi Shimogawa, Nobutaka Mukae, Satoshi Inoha, Takakazu Sasaguri, Satoshi Suzuki, Koji Iihara

Research output: Contribution to journalArticle

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Abstract

Background: An ependyma-lined canal with surrounding neuroglial tissues can be present in lumbosacral lipomatous malformations; however, the precise embryological significance is still unclear. Method: Six out of 50 patients with lipomatous malformations had ependymal structures. We retrospectively analyzed the clinical, neuroradiological, and histological findings of these patients to demonstrate the relationship with the embryological background of the retained medullary cord (RMC), which normally regresses, but was retained here because of late arrest of secondary neurulation. Results: Five (13.9%) of 36 patients with filar and caudal types and 1 of 3 lipomyelomeningoceles had ependymal structures, while none with dorsal and transitional types had these tissues. Histologically, the ependymal structures surrounded by neuroglial tissue and containing various amounts of adipose tissue bear a striking resemblance to the ependymal structures in RMC. Conclusion: The 13.9% incidence of association between the ependymal structures and filar and caudal types is thought to be because of second ary neurulation failure with the same embryological background as that of RMC. Dorsal and transitional types, resulting from primary neurulation failure, therefore, did not have ependymal structures.

Original languageEnglish
Pages (from-to)387-394
Number of pages8
JournalPediatric Neurosurgery
Volume53
Issue number6
DOIs
Publication statusPublished - Dec 1 2018

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Neurulation
Ependyma
Adipose Tissue
Incidence

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Surgery
  • Clinical Neurology

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Ependyma-lined canal with surrounding neuroglial tissues in lumbosacral lipomatous malformations : Relationship with retained medullary cord. / Murakami, Nobuya; Morioka, Takato; Shimogawa, Takafumi; Mukae, Nobutaka; Inoha, Satoshi; Sasaguri, Takakazu; Suzuki, Satoshi; Iihara, Koji.

In: Pediatric Neurosurgery, Vol. 53, No. 6, 01.12.2018, p. 387-394.

Research output: Contribution to journalArticle

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abstract = "Background: An ependyma-lined canal with surrounding neuroglial tissues can be present in lumbosacral lipomatous malformations; however, the precise embryological significance is still unclear. Method: Six out of 50 patients with lipomatous malformations had ependymal structures. We retrospectively analyzed the clinical, neuroradiological, and histological findings of these patients to demonstrate the relationship with the embryological background of the retained medullary cord (RMC), which normally regresses, but was retained here because of late arrest of secondary neurulation. Results: Five (13.9{\%}) of 36 patients with filar and caudal types and 1 of 3 lipomyelomeningoceles had ependymal structures, while none with dorsal and transitional types had these tissues. Histologically, the ependymal structures surrounded by neuroglial tissue and containing various amounts of adipose tissue bear a striking resemblance to the ependymal structures in RMC. Conclusion: The 13.9{\%} incidence of association between the ependymal structures and filar and caudal types is thought to be because of second ary neurulation failure with the same embryological background as that of RMC. Dorsal and transitional types, resulting from primary neurulation failure, therefore, did not have ependymal structures.",
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AU - Mukae, Nobutaka

AU - Inoha, Satoshi

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AU - Suzuki, Satoshi

AU - Iihara, Koji

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