Epidemiological evidence of the relationship between diabetes and dementia

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Growing epidemiological evidence has suggested that subjects with diabetes mellitus are at an increased risk for the development of dementia. However, the results for the subtypes of dementia are inconsistent. This review examined the risk of dementia in subjects with diabetes mellitus and discusses the possible mechanism underlying this association. Diabetes mellitus is associated with a 1.5- to 2.5-fold greater risk of dementia among community-dwelling elderly people. Notably, diabetes mellitus is a significant risk factor for not only vascular dementia but also Alzheimer’s disease. The mechanisms underlying the association are unclear, but it may be multifactorial in nature, involving factors such as cardiovascular risk factors, glucose toxicity, changes in insulin metabolism, and inflammation. The optimal management of these risk factors in early life may be important to prevent future dementia. Furthermore, novel therapeutic strategies will be needed to prevent or reduce the development of dementia in subjects with diabetes mellitus.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages13-25
Number of pages13
DOIs
Publication statusPublished - Jan 1 2019

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1128
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

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Medical problems
Dementia
Diabetes Mellitus
Independent Living
Vascular Dementia
Metabolism
Toxicity
Alzheimer Disease
Insulin
Inflammation
Glucose

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Ninomiya, T. (2019). Epidemiological evidence of the relationship between diabetes and dementia. In Advances in Experimental Medicine and Biology (pp. 13-25). (Advances in Experimental Medicine and Biology; Vol. 1128). Springer New York LLC. https://doi.org/10.1007/978-981-13-3540-2_2

Epidemiological evidence of the relationship between diabetes and dementia. / Ninomiya, Toshiharu.

Advances in Experimental Medicine and Biology. Springer New York LLC, 2019. p. 13-25 (Advances in Experimental Medicine and Biology; Vol. 1128).

Research output: Chapter in Book/Report/Conference proceedingChapter

Ninomiya, T 2019, Epidemiological evidence of the relationship between diabetes and dementia. in Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology, vol. 1128, Springer New York LLC, pp. 13-25. https://doi.org/10.1007/978-981-13-3540-2_2
Ninomiya T. Epidemiological evidence of the relationship between diabetes and dementia. In Advances in Experimental Medicine and Biology. Springer New York LLC. 2019. p. 13-25. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-981-13-3540-2_2
Ninomiya, Toshiharu. / Epidemiological evidence of the relationship between diabetes and dementia. Advances in Experimental Medicine and Biology. Springer New York LLC, 2019. pp. 13-25 (Advances in Experimental Medicine and Biology).
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