Epidemiological study of hepatitis e virus infection in the general population of Okinawa, Kyushu, Japan

Kazuhiro Toyoda, Norihiro Furusyo, Hiroaki Takeoka, Murata Masayuki, Yasunori Sawayama, Jun Hayashi

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14 Citations (Scopus)


Background and Aim: The aim of this study was to investigate the prevalence of hepatitis E virus (HEV) infection in the general population of Japan by determining presence of the antibody to HEV (anti-HEV). Methods: The prevalence of HEV infection was determined by positivity of serum antibody to HEV (anti-HEV). Results: On retrospective analysis, a significant decrease in anti-HEV prevalence was found in Okinawa healthy residents from 1995 (15.8%) to 2005 (5.5%) (P < 0.0001). In 2005, the anti-HEV prevalence was significantly higher in Okinawa wild boar hunters (25.3%) than in the residents (male 7.7% and female 4.1%) (P < 0.0001). A significant difference was found in the history of consumption of undercooked or raw boar meat between anti-HEV positive and negative hunters (100% vs 64.3%) (P = 0.0018). Conclusions: In conclusion, the anti-HEV prevalence has decreased in the residents of this area, but HEV infection has continued at a high rate in the hunters through the custom of eating undercooked or raw boar meat.

Original languageEnglish
Pages (from-to)1885-1890
Number of pages6
JournalJournal of Gastroenterology and Hepatology (Australia)
Issue number12
Publication statusPublished - Jan 1 2008

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology


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