Epigenetic events in mammalian germ-cell development: Reprogramming and beyond

Hiroyuki Sasaki, Yasuhisa Matsui

Research output: Contribution to journalReview article

523 Citations (Scopus)

Abstract

The epigenetic profile of germ cells, which is defined by modifications of DNA and chromatin, changes dynamically during their development. Many of the changes are associated with the acquisition of the capacity to support post-fertilization development. Our knowledge of this aspect has greatly increased - for example, insights into how the re-establishment of parental imprints is regulated. In addition, an emerging theme from recent studies is that epigenetic modifiers have key roles in germ-cell development itself - for example, epigenetics contributes to the gene-expression programme that is required for germ-cell development, regulation of meiosis and genomic integrity. Understanding epigenetic regulation in germ cells has implications for reproductive engineering technologies and human health.

Original languageEnglish
Pages (from-to)129-140
Number of pages12
JournalNature Reviews Genetics
Volume9
Issue number2
DOIs
Publication statusPublished - Feb 1 2008
Externally publishedYes

Fingerprint

Epigenomics
epigenetics
Germ Cells
germ cells
Reproductive Techniques
modifiers (genes)
Human Engineering
Meiosis
Fertilization
meiosis
Chromatin
chromatin
human health
engineering
genomics
Gene Expression
gene expression
Cellular Reprogramming
DNA
Health

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

Cite this

Epigenetic events in mammalian germ-cell development : Reprogramming and beyond. / Sasaki, Hiroyuki; Matsui, Yasuhisa.

In: Nature Reviews Genetics, Vol. 9, No. 2, 01.02.2008, p. 129-140.

Research output: Contribution to journalReview article

@article{9c6b8870b99747df84e79be039d5cb2b,
title = "Epigenetic events in mammalian germ-cell development: Reprogramming and beyond",
abstract = "The epigenetic profile of germ cells, which is defined by modifications of DNA and chromatin, changes dynamically during their development. Many of the changes are associated with the acquisition of the capacity to support post-fertilization development. Our knowledge of this aspect has greatly increased - for example, insights into how the re-establishment of parental imprints is regulated. In addition, an emerging theme from recent studies is that epigenetic modifiers have key roles in germ-cell development itself - for example, epigenetics contributes to the gene-expression programme that is required for germ-cell development, regulation of meiosis and genomic integrity. Understanding epigenetic regulation in germ cells has implications for reproductive engineering technologies and human health.",
author = "Hiroyuki Sasaki and Yasuhisa Matsui",
year = "2008",
month = "2",
day = "1",
doi = "10.1038/nrg2295",
language = "English",
volume = "9",
pages = "129--140",
journal = "Nature Reviews Genetics",
issn = "1471-0056",
publisher = "Nature Publishing Group",
number = "2",

}

TY - JOUR

T1 - Epigenetic events in mammalian germ-cell development

T2 - Reprogramming and beyond

AU - Sasaki, Hiroyuki

AU - Matsui, Yasuhisa

PY - 2008/2/1

Y1 - 2008/2/1

N2 - The epigenetic profile of germ cells, which is defined by modifications of DNA and chromatin, changes dynamically during their development. Many of the changes are associated with the acquisition of the capacity to support post-fertilization development. Our knowledge of this aspect has greatly increased - for example, insights into how the re-establishment of parental imprints is regulated. In addition, an emerging theme from recent studies is that epigenetic modifiers have key roles in germ-cell development itself - for example, epigenetics contributes to the gene-expression programme that is required for germ-cell development, regulation of meiosis and genomic integrity. Understanding epigenetic regulation in germ cells has implications for reproductive engineering technologies and human health.

AB - The epigenetic profile of germ cells, which is defined by modifications of DNA and chromatin, changes dynamically during their development. Many of the changes are associated with the acquisition of the capacity to support post-fertilization development. Our knowledge of this aspect has greatly increased - for example, insights into how the re-establishment of parental imprints is regulated. In addition, an emerging theme from recent studies is that epigenetic modifiers have key roles in germ-cell development itself - for example, epigenetics contributes to the gene-expression programme that is required for germ-cell development, regulation of meiosis and genomic integrity. Understanding epigenetic regulation in germ cells has implications for reproductive engineering technologies and human health.

UR - http://www.scopus.com/inward/record.url?scp=38349100549&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38349100549&partnerID=8YFLogxK

U2 - 10.1038/nrg2295

DO - 10.1038/nrg2295

M3 - Review article

C2 - 18197165

AN - SCOPUS:38349100549

VL - 9

SP - 129

EP - 140

JO - Nature Reviews Genetics

JF - Nature Reviews Genetics

SN - 1471-0056

IS - 2

ER -