Epigenetic events in mammalian germ-cell development: Reprogramming and beyond

Hiroyuki Sasaki, Yasuhisa Matsui

Research output: Contribution to journalReview article

552 Citations (Scopus)

Abstract

The epigenetic profile of germ cells, which is defined by modifications of DNA and chromatin, changes dynamically during their development. Many of the changes are associated with the acquisition of the capacity to support post-fertilization development. Our knowledge of this aspect has greatly increased - for example, insights into how the re-establishment of parental imprints is regulated. In addition, an emerging theme from recent studies is that epigenetic modifiers have key roles in germ-cell development itself - for example, epigenetics contributes to the gene-expression programme that is required for germ-cell development, regulation of meiosis and genomic integrity. Understanding epigenetic regulation in germ cells has implications for reproductive engineering technologies and human health.

Original languageEnglish
Pages (from-to)129-140
Number of pages12
JournalNature Reviews Genetics
Volume9
Issue number2
DOIs
Publication statusPublished - Feb 1 2008
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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