Epigenetic field cancerization in gastrointestinal cancers

Yoshifumi Baba, Takatsugu Ishimoto, Junji Kurashige, Masaaki Iwatsuki, Yasuo Sakamoto, Naoya Yoshida, Masayuki Watanabe, Hideo Baba

Research output: Contribution to journalShort survey

23 Citations (Scopus)

Abstract

Epigenetic alterations, including aberrant DNA methylation, play an important role in human cancer development. Importantly, epigenetic alterations are reversible and can be targets for therapy or chemoprevention for various types of human cancers. A field for cancerization, or a field defect, is formed by the accumulation of genetic and/or epigenetic alterations in normal-appearing tissues and can correlate with risk of cancer development. Thus, a better understanding of epigenetic field cancerization may represent a useful translational opportunity for cancer risk assessment, including previous history and exposure to carcinogenic factors, and for cancer prevention. In this article, we summarize current knowledge regarding epigenetic field cancerization and its clinical implications in gastrointestinal cancers, including colorectal cancer, gastric cancer and esophageal cancer.

Original languageEnglish
Pages (from-to)360-366
Number of pages7
JournalCancer Letters
Volume375
Issue number2
DOIs
Publication statusPublished - Jun 1 2016

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Gastrointestinal Neoplasms
Epigenomics
Neoplasms
Stomach Neoplasms
Chemoprevention
Human Development
DNA Methylation
Esophageal Neoplasms
Colorectal Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Baba, Y., Ishimoto, T., Kurashige, J., Iwatsuki, M., Sakamoto, Y., Yoshida, N., ... Baba, H. (2016). Epigenetic field cancerization in gastrointestinal cancers. Cancer Letters, 375(2), 360-366. https://doi.org/10.1016/j.canlet.2016.03.009

Epigenetic field cancerization in gastrointestinal cancers. / Baba, Yoshifumi; Ishimoto, Takatsugu; Kurashige, Junji; Iwatsuki, Masaaki; Sakamoto, Yasuo; Yoshida, Naoya; Watanabe, Masayuki; Baba, Hideo.

In: Cancer Letters, Vol. 375, No. 2, 01.06.2016, p. 360-366.

Research output: Contribution to journalShort survey

Baba, Y, Ishimoto, T, Kurashige, J, Iwatsuki, M, Sakamoto, Y, Yoshida, N, Watanabe, M & Baba, H 2016, 'Epigenetic field cancerization in gastrointestinal cancers', Cancer Letters, vol. 375, no. 2, pp. 360-366. https://doi.org/10.1016/j.canlet.2016.03.009
Baba Y, Ishimoto T, Kurashige J, Iwatsuki M, Sakamoto Y, Yoshida N et al. Epigenetic field cancerization in gastrointestinal cancers. Cancer Letters. 2016 Jun 1;375(2):360-366. https://doi.org/10.1016/j.canlet.2016.03.009
Baba, Yoshifumi ; Ishimoto, Takatsugu ; Kurashige, Junji ; Iwatsuki, Masaaki ; Sakamoto, Yasuo ; Yoshida, Naoya ; Watanabe, Masayuki ; Baba, Hideo. / Epigenetic field cancerization in gastrointestinal cancers. In: Cancer Letters. 2016 ; Vol. 375, No. 2. pp. 360-366.
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