Epigenetic mechanisms regulating fate specification of neural stem cells

Masakazu Namihira, Jun Kohyama, Masahiko Abematsu, Kinichi Nakashima

Research output: Contribution to journalReview article

61 Citations (Scopus)

Abstract

Neural stem cells (NSCs) possess the ability to self-renew and to differentiate along neuronal and glial lineages. These processes are defined by the dynamic interplay between extracellular cues including cytokine signalling and intracellular programmes such as epigenetic modification. There is increasing evidence that epigenetic mechanisms involving, for example, changes in DNA methylation, histone modification and non-coding RNA expression are closely associated with fate specification of NSCs. These epigenetic alterations could provide coordinated systems for regulating gene expression at each step of neural cell differentiation. Here we review the roles of epigenetics in neural fate specification in the mammalian central nervous system.

Original languageEnglish
Pages (from-to)2099-2109
Number of pages11
JournalPhilosophical Transactions of the Royal Society B: Biological Sciences
Volume363
Issue number1500
DOIs
Publication statusPublished - Jun 27 2008

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Neural Stem Cells
Stem cells
Epigenomics
epigenetics
stem cells
Specifications
Untranslated RNA
Neurology
Gene expression
Histones
Histone Code
Cytokines
Aptitude
neuroglia
DNA methylation
DNA Methylation
histones
Neuroglia
cell differentiation
central nervous system

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Epigenetic mechanisms regulating fate specification of neural stem cells. / Namihira, Masakazu; Kohyama, Jun; Abematsu, Masahiko; Nakashima, Kinichi.

In: Philosophical Transactions of the Royal Society B: Biological Sciences, Vol. 363, No. 1500, 27.06.2008, p. 2099-2109.

Research output: Contribution to journalReview article

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