Epigenetic regulation for acquiring glial identity by neural stem cells during cortical development

Takumi Nakagawa; Yoshikuni Wada; Sayako Katada; Yusuke Kishi

doi:10.1002/glia.23818

Epigenetic regulation for acquiring glial identity by neural stem cells during cortical development

Takumi Nakagawa, Yoshikuni Wada, Sayako Katada, Yusuke Kishi

Stem Cell Biology and Medicine

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

The nervous system consists of several hundred neuronal subtypes and glial cells that show specific gene expression and are generated from common ancestors, neural stem cells (NSCs). As the experimental techniques and molecular tools to analyze epigenetics and chromatin structures are rapidly advancing, the comprehensive events and genome-wide states of DNA methylation, histone modifications, and chromatin accessibility in developing NSCs are gradually being unveiled. Here, we review recent advances in elucidating the role of epigenetic and chromatin regulation in NSCs, especially focusing on the acquisition of glial identity and how epigenetic regulation enables the temporal regulation of NSCs during murine cortical development.

Original language	English
Pages (from-to)	1554-1567
Number of pages	14
Journal	GLIA
Volume	68
Issue number	8
DOIs	https://doi.org/10.1002/glia.23818
Publication status	Published - Aug 1 2020

All Science Journal Classification (ASJC) codes

Neurology
Cellular and Molecular Neuroscience

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10.1002/glia.23818

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title = "Epigenetic regulation for acquiring glial identity by neural stem cells during cortical development",

abstract = "The nervous system consists of several hundred neuronal subtypes and glial cells that show specific gene expression and are generated from common ancestors, neural stem cells (NSCs). As the experimental techniques and molecular tools to analyze epigenetics and chromatin structures are rapidly advancing, the comprehensive events and genome-wide states of DNA methylation, histone modifications, and chromatin accessibility in developing NSCs are gradually being unveiled. Here, we review recent advances in elucidating the role of epigenetic and chromatin regulation in NSCs, especially focusing on the acquisition of glial identity and how epigenetic regulation enables the temporal regulation of NSCs during murine cortical development.",

author = "Takumi Nakagawa and Yoshikuni Wada and Sayako Katada and Yusuke Kishi",

note = "Funding Information: We apologize to all researchers whose work we were not able to cite owing to space limitations. We thank E. Nakajima, Y. Gotoh, and K. Nakashima for critical reading of the manuscript. The work in the authors' laboratory is supported by MEXT/JSPS KAKENHI (JP19H05253 to Y.K.; JP17H05647 to S.K.), Kowa Life Science Foundation for S.K., and by JST AMED-PRIME (JP19gm6110021 to Y.K.). Publisher Copyright: {\textcopyright} 2020 Wiley Periodicals, Inc. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

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doi = "10.1002/glia.23818",

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AU - Nakagawa, Takumi

AU - Wada, Yoshikuni

AU - Katada, Sayako

AU - Kishi, Yusuke

N1 - Funding Information: We apologize to all researchers whose work we were not able to cite owing to space limitations. We thank E. Nakajima, Y. Gotoh, and K. Nakashima for critical reading of the manuscript. The work in the authors' laboratory is supported by MEXT/JSPS KAKENHI (JP19H05253 to Y.K.; JP17H05647 to S.K.), Kowa Life Science Foundation for S.K., and by JST AMED-PRIME (JP19gm6110021 to Y.K.). Publisher Copyright: © 2020 Wiley Periodicals, Inc. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020/8/1

Y1 - 2020/8/1

N2 - The nervous system consists of several hundred neuronal subtypes and glial cells that show specific gene expression and are generated from common ancestors, neural stem cells (NSCs). As the experimental techniques and molecular tools to analyze epigenetics and chromatin structures are rapidly advancing, the comprehensive events and genome-wide states of DNA methylation, histone modifications, and chromatin accessibility in developing NSCs are gradually being unveiled. Here, we review recent advances in elucidating the role of epigenetic and chromatin regulation in NSCs, especially focusing on the acquisition of glial identity and how epigenetic regulation enables the temporal regulation of NSCs during murine cortical development.

AB - The nervous system consists of several hundred neuronal subtypes and glial cells that show specific gene expression and are generated from common ancestors, neural stem cells (NSCs). As the experimental techniques and molecular tools to analyze epigenetics and chromatin structures are rapidly advancing, the comprehensive events and genome-wide states of DNA methylation, histone modifications, and chromatin accessibility in developing NSCs are gradually being unveiled. Here, we review recent advances in elucidating the role of epigenetic and chromatin regulation in NSCs, especially focusing on the acquisition of glial identity and how epigenetic regulation enables the temporal regulation of NSCs during murine cortical development.

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Epigenetic regulation for acquiring glial identity by neural stem cells during cortical development

Abstract

All Science Journal Classification (ASJC) codes

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