Epigenetic regulation in neural stem cell differentiation

Berry Juliandi, Masahiko Abematsu, Kinichi Nakashima

Research output: Contribution to journalReview articlepeer-review

62 Citations (Scopus)

Abstract

The central nervous system (CNS) is composed of three major cell types - neurons, astrocytes, and oligodendrocytes - which differentiate from common multipotent neural stem cells (NSCs). This differentiation process is regulated spatiotemporally during the course of mammalian development. It is becoming apparent that epigenetic regulation is an important cell-intrinsic program, which can interact with transcription factors and environmental cues to modulate the differentiation of NSCs. This knowledge is important given the potential of NSCs to produce specific CNS cell types that will be beneficial for clinical applications. Here we review recent findings that address molecular mechanisms of epigenetic and transcription factor-mediated regulation that specify NSC fate during CNS development, with a particular focus on the developing mammalian forebrain.

Original languageEnglish
Pages (from-to)493-504
Number of pages12
JournalDevelopment Growth and Differentiation
Volume52
Issue number6
DOIs
Publication statusPublished - Aug 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Developmental Biology
  • Cell Biology

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