TY - JOUR
T1 - Epigenetic regulation of cardiovascular differentiation
AU - Ohtani, Kisho
AU - Dimmeler, Stefanie
N1 - Funding Information:
This work was supported by the Deutsche Forschungsgemeinschaft (SFB834 Project B4).
PY - 2011/6/1
Y1 - 2011/6/1
N2 - Epigenetic control mechanisms play a key role in the regulation of embryonic development and tissue homeostasis and modulate cardiovascular diseases. Increasing evidence suggests that lineage commitment of stem/progenitor cells is tightly regulated by epigenetic mechanisms. These epigenetic control mechanisms include DNA and histone modifications, which modulate the chromatin structure thereby regulating access of transcription factors. Particularly, the modification of histone acetylation and methylation, which is controlled by families of histone acetylases/deacetylases and methyltransferases/demethylases, respectively, controls stem cell maintenance, differentiation, and function. This review article summarizes our current understanding of epigenetic mechanisms regulating the differentiation of cardiovascular cells, specifically endothelial cells and cardiac muscle lineages. In particular, the article will focus on the enzymes which modify histones and are involved in chromatin remodelling.
AB - Epigenetic control mechanisms play a key role in the regulation of embryonic development and tissue homeostasis and modulate cardiovascular diseases. Increasing evidence suggests that lineage commitment of stem/progenitor cells is tightly regulated by epigenetic mechanisms. These epigenetic control mechanisms include DNA and histone modifications, which modulate the chromatin structure thereby regulating access of transcription factors. Particularly, the modification of histone acetylation and methylation, which is controlled by families of histone acetylases/deacetylases and methyltransferases/demethylases, respectively, controls stem cell maintenance, differentiation, and function. This review article summarizes our current understanding of epigenetic mechanisms regulating the differentiation of cardiovascular cells, specifically endothelial cells and cardiac muscle lineages. In particular, the article will focus on the enzymes which modify histones and are involved in chromatin remodelling.
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U2 - 10.1093/cvr/cvr019
DO - 10.1093/cvr/cvr019
M3 - Article
C2 - 21372004
AN - SCOPUS:79957490739
SN - 0008-6363
VL - 90
SP - 404
EP - 412
JO - Cardiovascular Research
JF - Cardiovascular Research
IS - 3
ER -
