Epigenetic regulation of genes encoding drug-metabolizing enzymes and transporters; DNA methylation and other mechanisms

Takeshi Hirota, Hiroshi Takane, Shun Higuchi, Ichiro Ieiri

Research output: Contribution to journalReview articlepeer-review

23 Citations (Scopus)

Abstract

Drug metabolizing enzymes and transporters are increasingly recognized as key determinants of the inter-individual variability in pharmacokinetic (PK) and pharmacodynamic (PD) outcomes of clinically important drugs. To date, most studies investigating this variability have focused on polymorphisms (e.g. SNPs) in the genes encoding metabolic enzymes and transporters; however, it has recently been reported that the expression of some of these genes is under the control of epigenetic mechanisms. The most common epigenetic mechanism of mammalian genome regulation is DNA methylation, which does not change the genetic code but affects gene expression. Owing to its maintenance of the genomic sequence, DNA methylation is expected to offer an explanation for the controversial phenotypes of certain genetic polymorphisms. It has been recognized that DNA methylation plays a role in the transcrptional regulation of some PK/PD genes. In this review, we describe the impact of various epigenetic mechanism, especially DNA methylation, on the expression (or activity) of drug metabolizing enzymes and transporter genes.

Original languageEnglish
Pages (from-to)34-38
Number of pages5
JournalCurrent Drug Metabolism
Volume9
Issue number1
DOIs
Publication statusPublished - Jan 1 2008

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Clinical Biochemistry

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