Abstract
Neural stem cells (NSCs) have the ability to self-renew and give rise to neurons and glial cells (astrocytes and oligodendrocytes) in the mammalian central nervous system. This multipotency is acquired by NSCs during development and is maintained throughout life. Proliferation, fate specification, and maturation of NSCs are regulated by both cell intrinsic and extrinsic factors. Epigenetic modification is a representative intrinsic factor, being involved in many biological aspects of central nervous system development and adult neurogenesis through the regulation of NSC dynamics. In this review, we summarize recent progress in the epigenetic regulation of NSC behavior in the embryonic and adult brain, with particular reference to DNA methylation, histone modification, and noncoding RNAs.
| Original language | English |
|---|---|
| Pages (from-to) | 1-10 |
| Number of pages | 10 |
| Journal | Neuroepigenetics |
| Volume | 5 |
| DOIs | |
| Publication status | Published - Jan 1 2016 |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Developmental Neuroscience
- Cognitive Neuroscience
- Cellular and Molecular Neuroscience
- Biological Psychiatry
Cite this
Epigenetic regulation of neural stem cell property from embryo to adult. / Murao, Naoya; Noguchi, Hirofumi; Nakashima, Kinichi.
In: Neuroepigenetics, Vol. 5, 01.01.2016, p. 1-10.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Epigenetic regulation of neural stem cell property from embryo to adult
AU - Murao, Naoya
AU - Noguchi, Hirofumi
AU - Nakashima, Kinichi
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Neural stem cells (NSCs) have the ability to self-renew and give rise to neurons and glial cells (astrocytes and oligodendrocytes) in the mammalian central nervous system. This multipotency is acquired by NSCs during development and is maintained throughout life. Proliferation, fate specification, and maturation of NSCs are regulated by both cell intrinsic and extrinsic factors. Epigenetic modification is a representative intrinsic factor, being involved in many biological aspects of central nervous system development and adult neurogenesis through the regulation of NSC dynamics. In this review, we summarize recent progress in the epigenetic regulation of NSC behavior in the embryonic and adult brain, with particular reference to DNA methylation, histone modification, and noncoding RNAs.
AB - Neural stem cells (NSCs) have the ability to self-renew and give rise to neurons and glial cells (astrocytes and oligodendrocytes) in the mammalian central nervous system. This multipotency is acquired by NSCs during development and is maintained throughout life. Proliferation, fate specification, and maturation of NSCs are regulated by both cell intrinsic and extrinsic factors. Epigenetic modification is a representative intrinsic factor, being involved in many biological aspects of central nervous system development and adult neurogenesis through the regulation of NSC dynamics. In this review, we summarize recent progress in the epigenetic regulation of NSC behavior in the embryonic and adult brain, with particular reference to DNA methylation, histone modification, and noncoding RNAs.
UR - http://www.scopus.com/inward/record.url?scp=84956598680&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84956598680&partnerID=8YFLogxK
U2 - 10.1016/j.nepig.2016.01.001
DO - 10.1016/j.nepig.2016.01.001
M3 - Review article
AN - SCOPUS:84956598680
VL - 5
SP - 1
EP - 10
JO - Neuroepigenetics
JF - Neuroepigenetics
SN - 2214-7845
ER -