Epigenetic regulation of neural stem cell property from embryo to adult

Naoya Murao; Hirofumi Noguchi; Kinichi Nakashima

doi:10.1016/j.nepig.2016.01.001

Epigenetic regulation of neural stem cell property from embryo to adult

Naoya Murao, Hirofumi Noguchi, Kinichi Nakashima

Stem Cell Biology and Medicine

Research output: Contribution to journal › Review article

22 Citations (Scopus)

Abstract

Neural stem cells (NSCs) have the ability to self-renew and give rise to neurons and glial cells (astrocytes and oligodendrocytes) in the mammalian central nervous system. This multipotency is acquired by NSCs during development and is maintained throughout life. Proliferation, fate specification, and maturation of NSCs are regulated by both cell intrinsic and extrinsic factors. Epigenetic modification is a representative intrinsic factor, being involved in many biological aspects of central nervous system development and adult neurogenesis through the regulation of NSC dynamics. In this review, we summarize recent progress in the epigenetic regulation of NSC behavior in the embryonic and adult brain, with particular reference to DNA methylation, histone modification, and noncoding RNAs.

Original language	English
Pages (from-to)	1-10
Number of pages	10
Journal	Neuroepigenetics
Volume	5
DOIs	https://doi.org/10.1016/j.nepig.2016.01.001
Publication status	Published - Jan 1 2016

All Science Journal Classification (ASJC) codes

Biochemistry
Developmental Neuroscience
Cognitive Neuroscience
Cellular and Molecular Neuroscience
Biological Psychiatry

Access to Document

10.1016/j.nepig.2016.01.001

Fingerprint Dive into the research topics of 'Epigenetic regulation of neural stem cell property from embryo to adult'. Together they form a unique fingerprint.

Cite this

Murao, N., Noguchi, H., & Nakashima, K. (2016). Epigenetic regulation of neural stem cell property from embryo to adult. Neuroepigenetics, 5, 1-10. https://doi.org/10.1016/j.nepig.2016.01.001

@article{c0b304ed583f4892a4b8055aa46d5159,

title = "Epigenetic regulation of neural stem cell property from embryo to adult",

abstract = "Neural stem cells (NSCs) have the ability to self-renew and give rise to neurons and glial cells (astrocytes and oligodendrocytes) in the mammalian central nervous system. This multipotency is acquired by NSCs during development and is maintained throughout life. Proliferation, fate specification, and maturation of NSCs are regulated by both cell intrinsic and extrinsic factors. Epigenetic modification is a representative intrinsic factor, being involved in many biological aspects of central nervous system development and adult neurogenesis through the regulation of NSC dynamics. In this review, we summarize recent progress in the epigenetic regulation of NSC behavior in the embryonic and adult brain, with particular reference to DNA methylation, histone modification, and noncoding RNAs.",

author = "Naoya Murao and Hirofumi Noguchi and Kinichi Nakashima",

year = "2016",

month = jan,

day = "1",

doi = "10.1016/j.nepig.2016.01.001",

language = "English",

volume = "5",

pages = "1--10",

journal = "Neuroepigenetics",

issn = "2214-7845",

publisher = "Elsevier BV",

}

TY - JOUR

T1 - Epigenetic regulation of neural stem cell property from embryo to adult

AU - Murao, Naoya

AU - Noguchi, Hirofumi

AU - Nakashima, Kinichi

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Neural stem cells (NSCs) have the ability to self-renew and give rise to neurons and glial cells (astrocytes and oligodendrocytes) in the mammalian central nervous system. This multipotency is acquired by NSCs during development and is maintained throughout life. Proliferation, fate specification, and maturation of NSCs are regulated by both cell intrinsic and extrinsic factors. Epigenetic modification is a representative intrinsic factor, being involved in many biological aspects of central nervous system development and adult neurogenesis through the regulation of NSC dynamics. In this review, we summarize recent progress in the epigenetic regulation of NSC behavior in the embryonic and adult brain, with particular reference to DNA methylation, histone modification, and noncoding RNAs.

AB - Neural stem cells (NSCs) have the ability to self-renew and give rise to neurons and glial cells (astrocytes and oligodendrocytes) in the mammalian central nervous system. This multipotency is acquired by NSCs during development and is maintained throughout life. Proliferation, fate specification, and maturation of NSCs are regulated by both cell intrinsic and extrinsic factors. Epigenetic modification is a representative intrinsic factor, being involved in many biological aspects of central nervous system development and adult neurogenesis through the regulation of NSC dynamics. In this review, we summarize recent progress in the epigenetic regulation of NSC behavior in the embryonic and adult brain, with particular reference to DNA methylation, histone modification, and noncoding RNAs.

UR - http://www.scopus.com/inward/record.url?scp=84956598680&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84956598680&partnerID=8YFLogxK

U2 - 10.1016/j.nepig.2016.01.001

DO - 10.1016/j.nepig.2016.01.001

M3 - Review article

AN - SCOPUS:84956598680

VL - 5

SP - 1

EP - 10

JO - Neuroepigenetics

JF - Neuroepigenetics

SN - 2214-7845

ER -